{"type":"trials","record":{"id":30172,"source_id":"clinicaltrials-gov","external_id":"NCT06889545","title":"Comparison of Preoperative Frailty Assessment Tools","brief_summary":"Frailty is a significant risk factor for postoperative complications and functional decline. Preoperative assessment of frailty is therefore recommended in all older adults. However, despite the availability of many frailty tools, few have been tested in the preoperative setting and there is little comparison of their predictive value in identifying patients at risk. The aim of this study is to investigate which of the following instruments for determining frailty has the highest predictive power with regard to the occurrence of postoperative complications: Risk Analysis Index, Clinical Frailty Scale, the Groningen Frailty Indicator, the Edmonton Frail Scale and the LUCAS-FI. The aim of this research project is to identify a suitable frailty instrument for preoperative risk stratification of older patients during the premedication visit.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Universitätsklinikum Hamburg-Eppendorf","enrollment":584,"countries":["Germany"],"start_date":"2025-04-15","completion_date":"2028-04-01","last_update_date":"2026-07-22","source_url":"https://clinicaltrials.gov/study/NCT06889545","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:16.485702+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"PREFAS","age_range":"70 Years","comparator":null,"organization":"Universitätsklinikum Hamburg-Eppendorf","interventions":["Assessment of frailty using multiple tools"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Complications in the first 30 days after surgery — 30 days","Functional state (activities of daily living) — one, three and six months after surgery","Postoperative Quality of Recovery — postoperative day 2","Muscle loss during hospitalisation — From date of enrollment, up to 4 weeks after surgery","Postoperative delirium — postoperative day 1 to 5","Length of stay — from day of surgery, up to 4 weeks after surgery","Discharge destination — up to 4 weeks after surgery","Cognitive state — 3 and 6 months after surgery","Quality-of-Life (QoL) — 3 and 6 months after surgery","Frailty progression measured by LUCAS-FI — 3 and 6 months after surgery","Frailty progression measured by GFI (questionnaire) — 3 and 6 months after surgery","Frailty progression measured by EFS — 3 and 6 months after surgery","Frailty progression by RAI measurement. The Risk Analysis Index (RAI) is evaluated by summing weighted risk factors and…"],"design_description":null,"source_has_results":false},"controlled_terms":["Frailty","Frailty in Older Adults","Frailty/Sarcopenia","Assessment of frailty using multiple tools"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct06889545","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-15 to 2028-04-01","comparator":null,"confidence":"structured-source","population":"ALL · 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.767Z","intervention":["Assessment of frailty using multiple tools"],"participants":584,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Complications in the first 30 days after surgery — 30 days","Functional state (activities of daily living) — one, three and six months after surgery","Postoperative Quality of Recovery — postoperative day 2","Muscle loss during hospitalisation — From date of enrollment, up to 4 weeks after surgery","Postoperative delirium — postoperative day 1 to 5","Length of stay — from day of surgery, up to 4 weeks after surgery","Discharge destination — up to 4 weeks after surgery","Cognitive state — 3 and 6 months after surgery","Quality-of-Life (QoL) — 3 and 6 months after surgery","Frailty progression measured by LUCAS-FI — 3 and 6 months after surgery","Frailty progression measured by GFI (questionnaire) — 3 and 6 months after surgery","Frailty progression measured by EFS — 3 and 6 months after surgery","Frailty progression by RAI measurement. The Risk Analysis Index (RAI) is evaluated by summing weighted risk factors and…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/30172","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}