{"type":"trials","record":{"id":30307,"source_id":"clinicaltrials-gov","external_id":"NCT07689487","title":"Effects of Cyclical Blood Flow Restriction Exercise on Muscle Hypertrophy and Capillaries in Older Adults","brief_summary":"The purpose of this study was to learn if low-load resistance exercise combined with cyclical blood flow restriction (BFR) could improve small blood vessel structure and muscle size in older adults. Skeletal muscle thinning and the loss of tiny blood vessels (capillaries) commonly happen as people age. While lifting heavy weights can help stop this, heavy loads are often not suitable for older adults with joint pain or other health conditions. Low-load exercise with BFR involves wearing inflatable cuffs on the upper arms that temporarily slow down blood flow, which can trigger positive changes in muscles and blood vessels without needing heavy weights. Researchers compared three groups of older adults: * One group performed low-load upper-body exercises while wearing cyclical BFR cuffs. * A second group performed the exact same exercises at the same low load but without wearing cuffs. * A third group maintained their normal daily activities without participating in any structured exercise program. Participants in the exercise groups trained 3 days a week for 8 weeks. Researchers used video capillaroscopy (a specialized camera at the fingernail base) to examine changes in tiny blood vessels and ultrasound imaging to measure arm muscle thickness before and after the 8-week period.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Akdeniz University","enrollment":31,"countries":["Turkey (Türkiye)"],"start_date":"2026-02-01","completion_date":"2026-06-01","last_update_date":"2026-07-08","source_url":"https://clinicaltrials.gov/study/NCT07689487","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:16.485702+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":"Low-Load Training Group; Non-Exercise Control Grou","organization":"Akdeniz University","interventions":["Blood Flow Restriction (BFR)","Conventional Low-Load Resistance Exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Nailfold Capillary Diameter — Baseline and post-intervention (at the end of week 8)","Upper-Arm Muscle Thickness — Baseline and post-intervention (at the end of week 8).","Total Body Mass — Baseline and post-intervention (at the end of week 8)","Body Fat Percentage — Baseline and post-intervention (at the end of week 8)","Fat Mass — Baseline and post-intervention (at the end of week 8)"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","source_has_results":false},"controlled_terms":["Sarcopenia in Elderly","Muscle Atrophy","Aging","Blood Flow Restriction (BFR)","Conventional Low-Load Resistance Exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07689487","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-02-01 to 2026-06-01","comparator":"Low-Load Training Group; Non-Exercise Control Grou","confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.770Z","intervention":["Blood Flow Restriction (BFR)","Conventional Low-Load Resistance Exercise"],"participants":31,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Nailfold Capillary Diameter — Baseline and post-intervention (at the end of week 8)","Upper-Arm Muscle Thickness — Baseline and post-intervention (at the end of week 8).","Total Body Mass — Baseline and post-intervention (at the end of week 8)","Body Fat Percentage — Baseline and post-intervention (at the end of week 8)","Fat Mass — Baseline and post-intervention (at the end of week 8)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/30307","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}