{"type":"trials","record":{"id":30412,"source_id":"clinicaltrials-gov","external_id":"NCT06580964","title":"Heat and Exercise in Aging as Therapy (HEAT)","brief_summary":"The main goal of this two-phase clinical trial is to learn whether local heat therapy, using heat pads applied to the legs, can enhance skeletal muscle health, physical function, and blood sugar control in a manner comparable to exercise, specifically High-Intensity Interval Training (HIIT), in older individuals with prediabetes. The study aims to answer the following questions: 1. Does local heat therapy improve muscle architecture (e.g., muscle cross-sectional area, capillary density, mitochondrial content), glucose tolerance, and frailty indicators similarly to HIIT in older individuals with prediabetes? 2. Does local heat therapy as a pre-conditioning method enhance the skeletal muscle response to HIIT in older individuals with prediabetes?","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Texas Tech University","enrollment":54,"countries":["United States"],"start_date":"2025-11-06","completion_date":"2029-07-31","last_update_date":"2026-06-23","source_url":"https://clinicaltrials.gov/study/NCT06580964","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:16.485702+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"HEAT","age_range":"50 Years","comparator":"High-Intensity Interval Training","organization":"Texas Tech University","interventions":["Heat therapy","High-intensity interval training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Glycemic control — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24 weeks, except…","Skeletal muscle architecture 1 — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24…","Skeletal muscle architecture 2 — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24…","Frailty status — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24 weeks, except H…","Exercise capacity — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24 weeks, excep…","Anthropometrics 1 — Weekly for about 14 (HIIT group) or about 27 (LHT and CON groups) weeks","Anthropometrics 2 — Weekly for about 14 (HIIT group) or about 27 (LHT and CON groups) weeks","Body composition — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24 weeks, except…","Sleep quality — Weekly for about 14 (HIIT group) or about 27 (LHT and CON groups) weeks"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Prediabetic State","Heat therapy","High-intensity interval training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06580964","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-11-06 to 2029-07-31","comparator":"High-Intensity Interval Training","confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.419Z","intervention":["Heat therapy","High-intensity interval training"],"participants":54,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Glycemic control — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24 weeks, except…","Skeletal muscle architecture 1 — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24…","Skeletal muscle architecture 2 — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24…","Frailty status — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24 weeks, except H…","Exercise capacity — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24 weeks, excep…","Anthropometrics 1 — Weekly for about 14 (HIIT group) or about 27 (LHT and CON groups) weeks","Anthropometrics 2 — Weekly for about 14 (HIIT group) or about 27 (LHT and CON groups) weeks","Body composition — Before intervention, after Phase 1 (at about 12 weeks), and after Phase 2 (at about 24 weeks, except…","Sleep quality — Weekly for about 14 (HIIT group) or about 27 (LHT and CON groups) weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/30412","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}