{"type":"trials","record":{"id":30527,"source_id":"clinicaltrials-gov","external_id":"NCT07325760","title":"Effectiveness of a ReMIND Diet Intervention on Sarcopenia, Cognitive Frailty and Nutritional Status in Older Adults","brief_summary":"This research is a single-blinded, 12-week, two-arm cluster randomized controlled trial to evaluate the effectiveness of a Malaysian-adapted MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet retort meal intervention on sarcopenia risk, cognitive frailty status, nutritional status, depression, functional ability, and food security among older adults in Malaysia. With Malaysia projected to become an aged society by 2030, addressing age-related health challenges, including cognitive frailty and sarcopenia, is a national priority. Current evidence indicates that poor diet quality and food insecurity among older adults, especially those in low-income urban communities, exacerbate these conditions. The study is grounded on the Meals on Wheels (MoW) program, which has been effective in reducing malnutrition among older populations globally but is limited in scalability due to high delivery costs. Retort meals which are shelf-stable and nutritionally balanced offer a feasible alternative for meal provision in poor urban settings. The MIND diet, originally designed to support brain health, also demonstrates benefits for muscle health and overall physical function. However, its adaptation to the Malaysian context is crucial due to cultural dietary preferences and cost barriers to certain ingredients. The intervention will recruit 70 older adults (aged 60-84 years) from Program Perumahan Rakyat (PPR) Seri Alam Fasa 2 and Perumahan Awam (PA) Loke Yew in Kuala Lumpur, classified under the B40 income group and at risk of food insecurity. The intervention group will receive retort meals designed according to the adapted MIND diet principles, while the control group will not receive intervention. Data will be collected at baseline, 6 weeks, and 12 weeks to assess outcomes in muscle health, cognitive frailty, nutritional status, depression, functional ability, food security, and cost-effectiveness. Overall, the conceptual framework provides a structured approach to understanding how the intervention contributes to improved nutritional well-being and supports the economic viability of the Meals on Wheels program. Potential confounding variables, including socioeconomic status, baseline health conditions, social support, and lifestyle factors, may also influence the outcomes. Participants will fill up a questionnaire regarding their sociodemographic characteristics, medical factors, psychological factors, lifestyle factors, food security status, functional ability, and depression status. Besides, the researcher will conduct face-to-face interviews to collect data regarding anthropometric measurements, handgrip strength, medical costs, and diet history. Statistical analyses will employ mixed-effects models to evaluate both continuous and categorical outcomes over time. The findings will generate crucial evidence on the feasibility, effectiveness, and cost-efficiency of using retort meals within MoW programs in Malaysia. Furthermore, it will in…","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Universiti Putra Malaysia","enrollment":70,"countries":["Malaysia"],"start_date":"2026-06-15","completion_date":"2027-02-26","last_update_date":"2026-06-05","source_url":"https://clinicaltrials.gov/study/NCT07325760","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:16.485702+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"ReMIND","age_range":"60 Years to 84 Years","comparator":"PPA Loke Yew (Control Group)","organization":"Universiti Putra Malaysia","interventions":["PPR Seri Alam Fasa 2 (Intervention Group)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Appendicular skeletal muscle mass in kilograms (kg) — 3 months","Appendicular skeletal muscle index (ASMI) in kilograms per square meter (kg/m²) — 3 months","Muscle strength in kilograms (kg) — 3 months","Height in centimetres (cm) — 3 months","Body weight in kilograms (kg) — 3 months","Body mass index (BMI) in kilograms per square meter (kg/m²) — 3 months","Body fat percentage in percentage (%) — 3 months","Waist circumference in centimetres (cm) — 3 months","Calf circumference in centimetres (cm) — 3 months","Cognitive performance — 3 months","Malaysian-MIND diet (MY-MINDD) score — 3 months","Unintentional Weight Loss in kilogram (kg) — 3 months","Exhaustion — 3 months","Physical Performance in seconds (s) — 3 months","Physical Activity Score — 3 months","Frailty — 3 months","Incremental Cost-Effectiveness Ratio (ICER) — 3 months","Brain-Derived Neurotrophic Factor (BDNF) in picograms per milliliter (pg/mL) — 3 months","6-item USDA Household Food Security Survey Module (HFSSM) score — 3 months","Depressive Symptoms — 3 months"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Sarcopenia","Cognitive Frailty","Nutritional Interventions","PPR Seri Alam Fasa 2 (Intervention Group)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07325760","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-06-15 to 2027-02-26","comparator":"PPA Loke Yew (Control Group)","confidence":"structured-source","population":"ALL · 60 Years to 84 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.776Z","intervention":["PPR Seri Alam Fasa 2 (Intervention Group)"],"participants":70,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Appendicular skeletal muscle mass in kilograms (kg) — 3 months","Appendicular skeletal muscle index (ASMI) in kilograms per square meter (kg/m²) — 3 months","Muscle strength in kilograms (kg) — 3 months","Height in centimetres (cm) — 3 months","Body weight in kilograms (kg) — 3 months","Body mass index (BMI) in kilograms per square meter (kg/m²) — 3 months","Body fat percentage in percentage (%) — 3 months","Waist circumference in centimetres (cm) — 3 months","Calf circumference in centimetres (cm) — 3 months","Cognitive performance — 3 months","Malaysian-MIND diet (MY-MINDD) score — 3 months","Unintentional Weight Loss in kilogram (kg) — 3 months","Exhaustion — 3 months","Physical Performance in seconds (s) — 3 months","Physical Activity Score — 3 months","Frailty — 3 months","Incremental Cost-Effectiveness Ratio (ICER) — 3 months","Brain-Derived Neurotrophic Factor (BDNF) in picograms per milliliter (pg/mL) — 3 months","6-item USDA Household Food Security Survey Module (HFSSM) score — 3 months","Depressive Symptoms — 3 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}},{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/30527","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}