{"type":"trials","record":{"id":30716,"source_id":"clinicaltrials-gov","external_id":"NCT03129048","title":"Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults","brief_summary":"The deleterious effects of obesity on cardiovascular disease (CVD) and metabolic risk factors (dyslipidemia, hypertension, and insulin resistance) are well-documented. Recent evidence also links obesity to cognitive decline and dementia. Dietary patterns are central to the development and maintenance of obesity and certain dietary patterns may contribute to the onset and progression of cognitive decline. With the rapid aging of the US population and the high prevalence of obesity among older adults, innovative lifestyle strategies to prevent cognitive decline among ethnically diverse obese older adults are critically needed.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Illinois at Chicago","enrollment":180,"countries":["United States"],"start_date":"2016-09-01","completion_date":"2021-04-01","last_update_date":"2021-04-08","source_url":"https://clinicaltrials.gov/study/NCT03129048","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:19.114991+00:00","last_seen_at":"2026-09-25T06:25:45.678+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years to 85 Years","comparator":null,"organization":"University of Illinois at Chicago","interventions":["MedDiet"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Assessing change in Attention between time periods — 14 months","Assessing change in Executive Function between time periods — 14 months","Assessing change in Memory between time periods — 14 months"],"design_description":"RANDOMIZED · PARALLEL · OTHER · SINGLE","source_has_results":false},"controlled_terms":["Cognition","Obese Older Adults","Mediterranean Diet","MedDiet"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: mediterranean diet.","quality_checked_at":"2026-09-25T06:25:48.368501+00:00","duplicate_cluster_key":"id:nct03129048","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-09-01 to 2021-04-01","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:45.732Z","intervention":["MedDiet"],"participants":180,"study_design":"RANDOMIZED · PARALLEL · OTHER · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Assessing change in Attention between time periods — 14 months","Assessing change in Executive Function between time periods — 14 months","Assessing change in Memory between time periods — 14 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"mediterranean-diet","is_published":true,"match_reasons":["Title contains controlled term: mediterranean diet.","Source terminology contains: mediterranean diet.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Mediterranean diet","slug":"mediterranean-diet"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/30716","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}