{"type":"trials","record":{"id":31081,"source_id":"clinicaltrials-gov","external_id":"NCT03035851","title":"Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias","brief_summary":"The estimated annual cost of dementia in Canada is $15 billion, with a projected cumulative economic burden of $800 billion by 2038. Effective prevention of dementia at a population level will need to include lifestyle factors such as promoting higher levels of physical activity. Physical inactivity is a modifiable risk factor for Alzheimer disease (AD) and cognitive decline, but the mechanisms by which physical activity exerts its protective effect on the brain remain unknown. Motivated by the need to develop strategies to prevent and treat AD and related dementias (ADRD), the investigators' overall research goal is to discover why the aging brain develops ADRD. To achieve this goal the investigators adopt a translational physiology approach (i.e., study of physiology from molecule/cell to population) to investigate how exercise improves cognitive performance, and the underlying mechanisms by which exercise prevents and/or slows down age-related declines in brain health and cognition. This approach allows the investigators to determine how physiological function is related to ADRD, with important implications for health. The investigators' prior work demonstrated a significant relationship between fitness, vascular regulation and cognition in older adults free of overt disease. These findings have implications for vascular cognitive impairment and ADRD, in which hypoperfusion and dysregulation of cerebral blood flow are thought to be important pathophysiological factors. The investigators' central hypothesis is that regular aerobic exercise mitigates age-related decreases in vascular function and cerebrovascular reserve, which in turn benefits cognition. Work by the investigators and others has provided the necessary data justifying a randomized controlled trial to evaluate the role of exercise in the prevention of ADRD. The investigators are well equipped to undertake this trial; the investigators have dedicated institutional support and necessary expertise in vascular regulation, cognition, aging, neuroimaging and genetics. The overall objective of this proposal is to test an exercise intervention for secondary prevention of ADRD in adults between 50 and 80 years old who are at increased risk for ADRD (with memory impairment symptoms but without dementia). The rationale for this trial is the urgent need for dementia prevention: an exercise intervention, which harnesses a translational physiology framework, holds such promise. The investigators will conduct this trial to determine the effects of aerobic exercise on the development of age-associated cognitive decline and dementia. The exercise intervention is designed with input from Alberta Health Services, the universal healthcare provider for Albertans, so that the intervention can be readily adopted into clinical practice if this trial is successful. The trial will address three specific aims. SPECIFIC AIM 1: Determine the independent effect of exercise on cognitive performance in previousl…","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Calgary","enrollment":264,"countries":["Canada"],"start_date":"2017-01-01","completion_date":"2027-12-31","last_update_date":"2026-04-29","source_url":"https://clinicaltrials.gov/study/NCT03035851","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"BIMII","age_range":"50 Years to 80 Years","comparator":null,"organization":"University of Calgary","interventions":["Aerobic exercise","Stretch and Strength"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Cognition Assessed by Neuropsychological Test Battery — Measured at baseline, exercise intervention completio…","Change in Cerebral Blood Flow Assessed by Transcranial Doppler Ultrasound — Participants will be assessed at baseline,…","Change in Maximal Oxygen Uptake (VO2max) Assessed by Metabolic Cart — Participants will be assessed at baseline, at the…","Change in Blood Biomarkers Assessed by Elisa Assays — Participants will be assessed at baseline, at the completion of t…","Change in Risk/protective factors Assessed by Questionnaires — Participants will be assessed at baseline, at the comple…","Change in Brain Structure and Function Assessed by Neuroimaging Modalities — Participants will be assessed at baseline,…","Change in Sleep Quality Assessed by Polysomnography, Actigraphy and Questionnaires — Participants will be assessed at b…","Change in Health behaviour with appropriate support strategies — Participants will be assessed at 6, 12 and 18 months."],"design_description":"RANDOMIZED · PARALLEL · OTHER · SINGLE","source_has_results":false},"controlled_terms":["Alzheimer Disease","Dementia","Aerobic exercise","Stretch and Strength"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct03035851","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-01-01 to 2027-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.275Z","intervention":["Aerobic exercise","Stretch and Strength"],"participants":264,"study_design":"RANDOMIZED · PARALLEL · OTHER · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Cognition Assessed by Neuropsychological Test Battery — Measured at baseline, exercise intervention completio…","Change in Cerebral Blood Flow Assessed by Transcranial Doppler Ultrasound — Participants will be assessed at baseline,…","Change in Maximal Oxygen Uptake (VO2max) Assessed by Metabolic Cart — Participants will be assessed at baseline, at the…","Change in Blood Biomarkers Assessed by Elisa Assays — Participants will be assessed at baseline, at the completion of t…","Change in Risk/protective factors Assessed by Questionnaires — Participants will be assessed at baseline, at the comple…","Change in Brain Structure and Function Assessed by Neuroimaging Modalities — Participants will be assessed at baseline,…","Change in Sleep Quality Assessed by Polysomnography, Actigraphy and Questionnaires — Participants will be assessed at b…","Change in Health behaviour with appropriate support strategies — Participants will be assessed at 6, 12 and 18 months."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise, physical activity.","Source terminology contains: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31081","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}