{"type":"trials","record":{"id":31120,"source_id":"clinicaltrials-gov","external_id":"NCT06694441","title":"Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia","brief_summary":"This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD) - compared to age and sex matched controls with normal sleep. The study characterizes NA function through multiple approaches: measuring 24-hour plasma levels of norepinephrine (NE) and its brain metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG); evaluating central NA system response using the clonidine suppression test (a presynaptic α2 adrenoreceptor agonist that reduces locus coeruleus NA activity; and employing pupillometry as a non-invasive marker of autonomic function. To explore NA function's mechanistic role in insomnia, the study uses an intervention with bright light exposure to enhance daytime NA activity, with the goal of improving both sleep quality and cognitive performance.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Northwestern University","enrollment":60,"countries":["United States"],"start_date":"2024-09-30","completion_date":"2029-08-31","last_update_date":"2026-03-30","source_url":"https://clinicaltrials.gov/study/NCT06694441","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:00:59.325+00:00","metadata":{"sex":"ALL","acronym":"NASC","age_range":"55 Years","comparator":"Dim Red Light","organization":"Northwestern University","interventions":["Light Exposure","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["24h plasma norepinephrine — Enrollment to the end of treatment at 10 weeks.","Clonidine suppression test — Enrollment","Wake after sleep onset (WASO) — Enrollment to the end of treatment at 10 weeks.","Slow oscillatory activity during sleep — Enrollment to the end of treatment at 10 weeks.","Pittsburg Sleep Quality Index — Enrollment to the end of treatment at 10 weeks.","NIH tool box — Enrollment to the end of treatment at 10 weeks.","24-h plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) — Enrollment to the end of treatment at 10 weeks.","24-h plasma cortisol levels — Enrollment to the end of treatment at 10 weeks.","24h plasma melatonin — Enrollment to the end of treatment at 10 weeks.","Pupillometry — Enrollment to the end of treatment at 10 weeks.","Psychomotor Vigilance Test — Enrollment to the end of treatment at 10 weeks.","Wake EEG — Enrollment to the end of treatment at 10 weeks.","Heart Rate and Heart Rate Variability — Enrollment to the end of treatment at 10 weeks.","Insomnia Severity Index — Enrollment to the end of treatment at 10 weeks.","Visual Analogue Scale — Enrollment to the end of treatment at 10 weeks."],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Insomnia","Light Exposure","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T06:01:10.468881+00:00","duplicate_cluster_key":"id:nct06694441","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-30 to 2029-08-31","comparator":"Dim Red Light","confidence":"structured-source","population":"ALL · 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:59.353Z","intervention":["Light Exposure","Placebo"],"participants":60,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["24h plasma norepinephrine — Enrollment to the end of treatment at 10 weeks.","Clonidine suppression test — Enrollment","Wake after sleep onset (WASO) — Enrollment to the end of treatment at 10 weeks.","Slow oscillatory activity during sleep — Enrollment to the end of treatment at 10 weeks.","Pittsburg Sleep Quality Index — Enrollment to the end of treatment at 10 weeks.","NIH tool box — Enrollment to the end of treatment at 10 weeks.","24-h plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) — Enrollment to the end of treatment at 10 weeks.","24-h plasma cortisol levels — Enrollment to the end of treatment at 10 weeks.","24h plasma melatonin — Enrollment to the end of treatment at 10 weeks.","Pupillometry — Enrollment to the end of treatment at 10 weeks.","Psychomotor Vigilance Test — Enrollment to the end of treatment at 10 weeks.","Wake EEG — Enrollment to the end of treatment at 10 weeks.","Heart Rate and Heart Rate Variability — Enrollment to the end of treatment at 10 weeks.","Insomnia Severity Index — Enrollment to the end of treatment at 10 weeks.","Visual Analogue Scale — Enrollment to the end of treatment at 10 weeks."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31120","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}