{"type":"trials","record":{"id":31199,"source_id":"clinicaltrials-gov","external_id":"NCT05952284","title":"Couples Health Aging, Rhythms and Sleep Study","brief_summary":"Alzheimer's disease and related dementias (ADRD), including mild cognitive impairment (MCI), are becoming among the most prevalent causes of disability, death and healthcare costs worldwide. Sleep and circadian rhythm disturbances are common among individuals with MCI as well as their spouses/ partners and may increase risk of the development of ADRD in both patients and partners. This is the first study to systematically investigate sleep as a shared health behavior within couples in which one member has MCI, and the degree to which sleep and circadian disturbances impact both partners health and well-being, including cognitive decline and risk for ADRD.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Utah","enrollment":340,"countries":["United States"],"start_date":"2023-09-14","completion_date":"2027-07-21","last_update_date":"2026-02-13","source_url":"https://clinicaltrials.gov/study/NCT05952284","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:25:39.067+00:00","metadata":{"sex":"ALL","acronym":"CHARMS","age_range":"50 Years","comparator":null,"organization":"University of Utah","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Digit symbol: daily score — This study will evaluate day to day change in digit symbol performance over 10 days.","Memory: daily score — This study will evaluate day to day change in digit symbol performance over 10 days.","Cogntive function: RBANS total score — We will evaluate change from baseline to two years"],"design_description":null,"source_has_results":false},"controlled_terms":["Aging","Memory Loss"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T06:25:42.287439+00:00","duplicate_cluster_key":"id:nct05952284","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-09-14 to 2027-07-21","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:39.091Z","intervention":[],"participants":340,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Digit symbol: daily score — This study will evaluate day to day change in digit symbol performance over 10 days.","Memory: daily score — This study will evaluate day to day change in digit symbol performance over 10 days.","Cogntive function: RBANS total score — We will evaluate change from baseline to two years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep, circadian.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31199","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}