{"type":"trials","record":{"id":31208,"source_id":"clinicaltrials-gov","external_id":"NCT07390305","title":"Multidimensional Correlation Study on Skin Aging in Menopausal Women","brief_summary":"Primary Objective: This study primarily aims to compare skin aging characteristics between women at different stages of reproductive aging in both sun-exposed and non-exposed areas, based on skin indicators collected during a single laboratory visit. Furthermore, through a 30-day at-home tracking period (for the late-stage and postmenopausal groups) or one menstrual cycle (for the early-stage and young group), we seek to analyze the temporal dynamics of changes in skin condition, mood, sleep quality, and menopausal hot flashes. Secondary Objective: The secondary objective is to examine differences in skin conditions across life stages by recruiting mother-daughter pairs (where the young group consists of the biological daughters of the late-stage and postmenopausal groups). The core focus is to leverage shared genetic backgrounds to explore how skin characteristics, particularly in different body areas, may change over time or in response to hormonal fluctuations. By comparing these characteristics across age groups, this study seeks to identify key variation patterns and their contributing factors, thereby laying the groundwork for further mechanistic investigations and practical applications.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"ChinaNorm","enrollment":100,"countries":["China"],"start_date":"2025-11-11","completion_date":"2026-01-20","last_update_date":"2026-02-05","source_url":"https://clinicaltrials.gov/study/NCT07390305","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"18 Years to 60 Years","comparator":null,"organization":"ChinaNorm","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Clinical Assessment — The assessment is performed as a single evaluation at the T1 (baseline) laboratory visit .","Skin Wrinkle and Smoothness Assessment — The assessment is conducted as a single measurement at the T1 (baseline) time…","Skin Color Measurement with Colorimeter — The measurement is performed as a single assessment at the T1 (baseline) labo…","Skin Elasticity Measurement with Cutometer® MPA580 — The measurement is performed as a single assessment at the T1 (bas…","Skin Ultrasound Diagnostic System Ultrascan UC22 — The measurement is performed as a single assessment at the T1 (basel…","Skin Moisture Loss Meter Vapometer — The measurement is performed as a single assessment at the T1 (baseline) laborator…","Skin Hemoglobin Measurement with Mexameter® MX18 — The assessment is performed as a single measurement at the T1 (basel…","Intelligent Skin Analyzer Skinmeter — The measurement is performed at three designated time points during the study: T1…","Skin Sebum Measurement with Sebum-Test Paper — The measurement is performed at three designated time points during the…","Sleep Duration Recording — Sleep data is collected continuously throughout the entire tracking period of the study.Day1…","BMI — BMI is measured during the baseline laboratory visit.","Pittsburgh Sleep Quality Index (PSQI) — The PSQI questionnaire will be administered at three designated time points dur…","Generalized Anxiety Disorder-7 (GAD-7) — he questionnaire is administered at three designated time points during the st…","Patient Health Questionnaire-8 Items (PHQ-8) — The questionnaire is administered at three specific time points during t…","Assessment of Hot Flash Frequency and Impact on Daily Life — This questionnaire is to be completed daily throughout the…","Ultraviolet (UV) Exposure Questionnaire — The questionnaire assesses UV exposure behaviors and sun protection habits ov…"],"design_description":null,"source_has_results":false},"controlled_terms":["Skin Aging","Reproductive Aging","Menopause","Genetic Factors"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct07390305","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-11-11 to 2026-01-20","comparator":null,"confidence":"structured-source","population":"FEMALE · 18 Years to 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.567Z","intervention":[],"participants":100,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Clinical Assessment — The assessment is performed as a single evaluation at the T1 (baseline) laboratory visit .","Skin Wrinkle and Smoothness Assessment — The assessment is conducted as a single measurement at the T1 (baseline) time…","Skin Color Measurement with Colorimeter — The measurement is performed as a single assessment at the T1 (baseline) labo…","Skin Elasticity Measurement with Cutometer® MPA580 — The measurement is performed as a single assessment at the T1 (bas…","Skin Ultrasound Diagnostic System Ultrascan UC22 — The measurement is performed as a single assessment at the T1 (basel…","Skin Moisture Loss Meter Vapometer — The measurement is performed as a single assessment at the T1 (baseline) laborator…","Skin Hemoglobin Measurement with Mexameter® MX18 — The assessment is performed as a single measurement at the T1 (basel…","Intelligent Skin Analyzer Skinmeter — The measurement is performed at three designated time points during the study: T1…","Skin Sebum Measurement with Sebum-Test Paper — The measurement is performed at three designated time points during the…","Sleep Duration Recording — Sleep data is collected continuously throughout the entire tracking period of the study.Day1…","BMI — BMI is measured during the baseline laboratory visit.","Pittsburgh Sleep Quality Index (PSQI) — The PSQI questionnaire will be administered at three designated time points dur…","Generalized Anxiety Disorder-7 (GAD-7) — he questionnaire is administered at three designated time points during the st…","Patient Health Questionnaire-8 Items (PHQ-8) — The questionnaire is administered at three specific time points during t…","Assessment of Hot Flash Frequency and Impact on Daily Life — This questionnaire is to be completed daily throughout the…","Ultraviolet (UV) Exposure Questionnaire — The questionnaire assesses UV exposure behaviors and sun protection habits ov…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: skin aging.","Source terminology contains: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31208","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}