{"type":"trials","record":{"id":31216,"source_id":"clinicaltrials-gov","external_id":"NCT03848715","title":"Sleep and Healthy Aging Research on Depression for Younger Women","brief_summary":"Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood. This study comprehensively evaluates effects of inflammation on reward across dimensions (e.g., anticipating versus receiving a reward) and types (e.g., money vs. smiling faces) in younger and older women. Characterizing how inflammation shapes the dynamic and multidimensional reward system, and how this may differ by age, may give insight into risk factors for depression and help identify critical points for intervention.","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"University of California, Los Angeles","enrollment":40,"countries":["United States"],"start_date":"2019-10-02","completion_date":"2024-07-22","last_update_date":"2026-01-27","source_url":"https://clinicaltrials.gov/study/NCT03848715","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:00:59.325+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"25 Years to 44 Years","comparator":"Placebo","organization":"University of California, Los Angeles","interventions":["Endotoxin","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Non-social (Monetary) Reward Response (Reward Learning and Sensitivity) — Baseline and post-injection (2.25 hrs)","Non-social (Monetary) Reward Response (Reward Motivation) — Baseline and post-injection (2.1 hrs)","Non-social (Monetary) Reward Response (Reward Sensitivity) — Baseline and post-injection (2.1 hrs)","General Social Reward Response (Reward Sensitivity Via Emotional Dot Probe) — Baseline and post-injection (2.7 hrs)","General Social Reward Response (Reward Sensitivity Via Face Morphing Task) — Baseline and post-injection (2.8 hrs)","General Social Reward Response (Social Reward Motivation) — Baseline and post-injection (2 hrs)","Depressed Mood Subscale of the Profile of Mood States (POMS) — Hourly, from pre-injection (T0) to 9 hours later (T9)","Close Social Reward Response — Post-injection (2.9 hrs)","Consummatory Daily Reward Response — 14 days (7 days pre-injection; 7 days post-injection).","Dopaminergic Activity — Baseline and post-injection (1.9 hrs)","Anticipatory Daily Reward Response — 14 days (7 days pre-injection; 7 days post-injection)."],"design_description":"RANDOMIZED · PARALLEL · OTHER · TRIPLE","source_has_results":true},"controlled_terms":["Anhedonia","Depression","Endotoxin","Placebo"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T06:01:10.468881+00:00","duplicate_cluster_key":"id:nct03848715","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-10-02 to 2024-07-22","comparator":"Placebo","confidence":"structured-source","population":"FEMALE · 25 Years to 44 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:59.360Z","intervention":["Endotoxin","Placebo"],"participants":40,"study_design":"RANDOMIZED · PARALLEL · OTHER · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Non-social (Monetary) Reward Response (Reward Learning and Sensitivity) — Baseline and post-injection (2.25 hrs)","Non-social (Monetary) Reward Response (Reward Motivation) — Baseline and post-injection (2.1 hrs)","Non-social (Monetary) Reward Response (Reward Sensitivity) — Baseline and post-injection (2.1 hrs)","General Social Reward Response (Reward Sensitivity Via Emotional Dot Probe) — Baseline and post-injection (2.7 hrs)","General Social Reward Response (Reward Sensitivity Via Face Morphing Task) — Baseline and post-injection (2.8 hrs)","General Social Reward Response (Social Reward Motivation) — Baseline and post-injection (2 hrs)","Depressed Mood Subscale of the Profile of Mood States (POMS) — Hourly, from pre-injection (T0) to 9 hours later (T9)","Close Social Reward Response — Post-injection (2.9 hrs)","Consummatory Daily Reward Response — 14 days (7 days pre-injection; 7 days post-injection).","Dopaminergic Activity — Baseline and post-injection (1.9 hrs)","Anticipatory Daily Reward Response — 14 days (7 days pre-injection; 7 days post-injection)."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31216","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}