{"type":"trials","record":{"id":31257,"source_id":"clinicaltrials-gov","external_id":"NCT07255521","title":"Prehabilitation to Improve Frailty, Function, and Quality of Life in Candidates for Hematopoietic Stem Cell Transplantation","brief_summary":"Candidates for hematopoietic stem cell transplantation (HSCT) frequently experience declines in strength, physical function, and quality of life before the procedure. Many also present fatigue, limitations in daily activities, and an increased risk of complications during and after hospitalization. Optimizing physical condition before transplantation may improve post-procedure recovery. This study will evaluate whether a prehabilitation program improves physical function, frailty, and quality of life in adults preparing for HSCT. The intervention consists of supervised exercise, education, and activities designed to enhance endurance and functional capacity. Although prehabilitation has shown benefits in other oncologic populations, it has been minimally studied in HSCT candidates, and no structured programs have been evaluated in Chile. A total of 68 adults will be randomly assigned to a prehabilitation group or a usual-care control group. The prehabilitation group will receive a personalized program including aerobic and resistance exercise, stretching, balance training, respiratory exercises, and education on healthy behaviors, delivered through a hybrid model of in-person and remote sessions. Occupational therapy will also be provided to support functional and cognitive abilities. The control group will continue with standard medical care. Baseline and post-intervention assessments will include measures of strength, frailty, fatigue, balance, cognitive function, daily activities, and quality of life. Post-transplant outcomes such as hospital length of stay, complications, and readmissions within three months will also be recorded. Feasibility, adherence, satisfaction, and adverse events will be evaluated. Findings from this trial may inform the development of structured prehabilitation programs for HSCT candidates and support the implementation of evidence-based supportive care strategies in hematologic oncology.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Hospital del Salvador","enrollment":68,"countries":["Chile"],"start_date":"2025-12-26","completion_date":"2026-06-30","last_update_date":"2025-12-15","source_url":"https://clinicaltrials.gov/study/NCT07255521","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"PREHAB-HSCT","age_range":"18 Years","comparator":"Usual Care","organization":"Hospital del Salvador","interventions":["Multimodal Prehabilitation"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Functional Capacity — Baseline and post-intervention (4-6 weeks)","Frailty — Baseline and immediately post-intervention (approximately 4-6 weeks).","Lower Limb Strength — Baseline and post-intervention (4-6 weeks)","Handgrip Strength — Baseline and post-intervention (4-6 weeks)","Fatigue — Baseline and post-intervention (4-6 weeks)","Dynamic Balance and Fall Risk — Baseline and post-intervention (4-6 weeks)","Subjective physical activity level — Baseline and post-intervention (4-6 weeks)","Objective Physical Activity — 7-day monitoring at baseline and 7-day monitoring post-intervention","Post-Transplant Outcomes — During index hospitalization for HSCT","Cognitive Function — Baseline and post-intervention (4-6 weeks)","Functioning and Disability — Baseline and post-intervention (4-6 weeks)","Quality of Life measured by the FACT-BMT — Baseline and post-intervention (4-6 weeks)","Feasibility: adherence, satisfaction, and adverse events — Throughout the intervention period (4-6 weeks)"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Hematopoietic Stem Cell Transplantation (HSCT)","Multimodal Prehabilitation"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07255521","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-12-26 to 2026-06-30","comparator":"Usual Care","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.475Z","intervention":["Multimodal Prehabilitation"],"participants":68,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Functional Capacity — Baseline and post-intervention (4-6 weeks)","Frailty — Baseline and immediately post-intervention (approximately 4-6 weeks).","Lower Limb Strength — Baseline and post-intervention (4-6 weeks)","Handgrip Strength — Baseline and post-intervention (4-6 weeks)","Fatigue — Baseline and post-intervention (4-6 weeks)","Dynamic Balance and Fall Risk — Baseline and post-intervention (4-6 weeks)","Subjective physical activity level — Baseline and post-intervention (4-6 weeks)","Objective Physical Activity — 7-day monitoring at baseline and 7-day monitoring post-intervention","Post-Transplant Outcomes — During index hospitalization for HSCT","Cognitive Function — Baseline and post-intervention (4-6 weeks)","Functioning and Disability — Baseline and post-intervention (4-6 weeks)","Quality of Life measured by the FACT-BMT — Baseline and post-intervention (4-6 weeks)","Feasibility: adherence, satisfaction, and adverse events — Throughout the intervention period (4-6 weeks)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31257","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}