{"type":"trials","record":{"id":31354,"source_id":"clinicaltrials-gov","external_id":"NCT05268991","title":"Aging and Frailty Study","brief_summary":"The purpose of this research study is to compare methods to help personalize the prediction of chemotherapy side effects for older adults and to evaluate whether chemotherapy causes changes in the body that are associated with aging.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Wake Forest University Health Sciences","enrollment":25,"countries":["United States"],"start_date":"2022-05-02","completion_date":"2025-06-13","last_update_date":"2025-08-01","source_url":"https://clinicaltrials.gov/study/NCT05268991","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"Wake Forest University Health Sciences","interventions":["Geriatric Assessments and Frailty Indices"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Resiliency Administered Assessments - Change of Short Physical Performance Battery (SPPB) — At baseline, 3 months and 6…","Resiliency Administered Assessments - Change of Grip Strength — At baseline, 3 months and 6 months after chemotherapy","Resiliency Administered Assessments - Change of Blessed Orientation Memory and Concentration Test (BOMC) — At baseline,…","Change of Electronic Frailty Index and Cancer Score/Category — At baseline, 3 months and 6 months after chemotherapy","Change in Patient Reported Outcomes Measurement - PROMIS 29 — At baseline, 3 months and 6 months after chemotherapy","Change of Biomarkers of Aging Observed During Study Intervention — At baseline, 3 months and 6 months after chemotherapy","Number of Incidences of Toxicity - Grades 2 to 5 Related to Standard of Care Chemotherapy — Up to 6 months after chemot…","Number of Documented Dose Reductions During Chemotherapy — Up to 6 months after chemotherapy","Number of Dose Delays During Chemotherapy — Up to 6 months after chemotherapy","Number of Early Discontinuations of Chemotherapy — Up to 6 months after chemotherapy","Number of Unplanned Hospitalizations — Up to 6 months after chemotherapy","Overall Survival — Up to 6 months after chemotherapy"],"design_description":null,"source_has_results":false},"controlled_terms":["Effects of Chemotherapy","Aging","Frailty","Geriatric Assessments and Frailty Indices"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct05268991","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-05-02 to 2025-06-13","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.495Z","intervention":["Geriatric Assessments and Frailty Indices"],"participants":25,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Resiliency Administered Assessments - Change of Short Physical Performance Battery (SPPB) — At baseline, 3 months and 6…","Resiliency Administered Assessments - Change of Grip Strength — At baseline, 3 months and 6 months after chemotherapy","Resiliency Administered Assessments - Change of Blessed Orientation Memory and Concentration Test (BOMC) — At baseline,…","Change of Electronic Frailty Index and Cancer Score/Category — At baseline, 3 months and 6 months after chemotherapy","Change in Patient Reported Outcomes Measurement - PROMIS 29 — At baseline, 3 months and 6 months after chemotherapy","Change of Biomarkers of Aging Observed During Study Intervention — At baseline, 3 months and 6 months after chemotherapy","Number of Incidences of Toxicity - Grades 2 to 5 Related to Standard of Care Chemotherapy — Up to 6 months after chemot…","Number of Documented Dose Reductions During Chemotherapy — Up to 6 months after chemotherapy","Number of Dose Delays During Chemotherapy — Up to 6 months after chemotherapy","Number of Early Discontinuations of Chemotherapy — Up to 6 months after chemotherapy","Number of Unplanned Hospitalizations — Up to 6 months after chemotherapy","Overall Survival — Up to 6 months after chemotherapy"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: aging, frailty.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31354","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}