{"type":"trials","record":{"id":31357,"source_id":"clinicaltrials-gov","external_id":"NCT04715581","title":"Multicomponent Prehabilitation and Outcomes in Elderly Patients With Frailty","brief_summary":"The study is designed to investigate the effect of a multicomponent prehabilitation pathway on early and long-term outcomes in elderly patients with frailty recovering from surgery for digestive cancer.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Peking University First Hospital","enrollment":540,"countries":["China"],"start_date":"2021-11-25","completion_date":"2028-12-01","last_update_date":"2025-07-31","source_url":"https://clinicaltrials.gov/study/NCT04715581","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 89 Years","comparator":"Control group","organization":"Peking University First Hospital","interventions":["Preoperative nutritional optimization","Preoperative exercise training","Postoperative exercise training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["A composite of delirium and non-delirium complications within 7 days after surgery (sub-study). — Up to 7 days after su…","Recurrence-free survival after surgery. — Up to two years after surgery.","Intensive care unit admission after surgery (sub-study). — Up to 30 days after surgery.","Incidence of delirium within 7 days after surgery (sub-study). — Up to 7 days after surgery.","Time to oral fluid intake after surgery (sub-study). — Up to 30 days after surgery.","Time to oral food intake after surgery (sub-study). — Up to 30 days after surgery.","Time to out-of-bed activity after surgery (sub-study). — Up to 30 days after surgery.","6-minute walk distance at hospital discharge (sub-study). — At hospital discharge, up to 30 days after surgery.","Length of hospital stay after surgery (sub-study). — Up to 30 days after surgery.","Incidence of non-delirium complication within 30 days after surgery (sub-study). — Up to 30 days after surgery.","All-cause 30-day mortality after surgery (sub-study). — Up to 30 days after surgery.","Quality of life at 30 days after surgery (sub-study). — At 30 days after surgery.","Cognitive function at 30 days after surgery (sub-study). — At 30 days after surgery.","Sleep quality at 30 days after surgery (sub-study). — At 30 days after surgery.","Overall survival after surgery. — Up to 2 years after surgery.","Cancer specific survival after surgery. — Up to 2 years after surgery.","Event-free survival after surgery. — Up to 2 years after surgery.","Physical activity at 30 days after surgery (sub-study). — At 30 days after surgery."],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · TRIPLE","source_has_results":false},"controlled_terms":["Old Age; Debility","Digestive Cancer","Surgery","Preoperative Rehabilitation","Nutrition Therapy","Outcomes","Preoperative nutritional optimization","Preoperative exercise training","Postoperative exercise training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct04715581","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-11-25 to 2028-12-01","comparator":"Control group","confidence":"structured-source","population":"ALL · 65 Years to 89 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.496Z","intervention":["Preoperative nutritional optimization","Preoperative exercise training","Postoperative exercise training"],"participants":540,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["A composite of delirium and non-delirium complications within 7 days after surgery (sub-study). — Up to 7 days after su…","Recurrence-free survival after surgery. — Up to two years after surgery.","Intensive care unit admission after surgery (sub-study). — Up to 30 days after surgery.","Incidence of delirium within 7 days after surgery (sub-study). — Up to 7 days after surgery.","Time to oral fluid intake after surgery (sub-study). — Up to 30 days after surgery.","Time to oral food intake after surgery (sub-study). — Up to 30 days after surgery.","Time to out-of-bed activity after surgery (sub-study). — Up to 30 days after surgery.","6-minute walk distance at hospital discharge (sub-study). — At hospital discharge, up to 30 days after surgery.","Length of hospital stay after surgery (sub-study). — Up to 30 days after surgery.","Incidence of non-delirium complication within 30 days after surgery (sub-study). — Up to 30 days after surgery.","All-cause 30-day mortality after surgery (sub-study). — Up to 30 days after surgery.","Quality of life at 30 days after surgery (sub-study). — At 30 days after surgery.","Cognitive function at 30 days after surgery (sub-study). — At 30 days after surgery.","Sleep quality at 30 days after surgery (sub-study). — At 30 days after surgery.","Overall survival after surgery. — Up to 2 years after surgery.","Cancer specific survival after surgery. — Up to 2 years after surgery.","Event-free survival after surgery. — Up to 2 years after surgery.","Physical activity at 30 days after surgery (sub-study). — At 30 days after surgery."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31357","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}