{"type":"trials","record":{"id":31394,"source_id":"clinicaltrials-gov","external_id":"NCT05993754","title":"Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams","brief_summary":"The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques. Likewise, elderly people (EP) may have a higher risk of postoperative morbidity and mortality compared to young people, with frailty being one of the risk factors that increases adverse outcomes in this period and increases the probability of developing syndromes such as postoperative delirium (POD). Assessment of frailty in EP prior to surgery is not routine, so it is unknown how many frail and/or pre-frail EP undergo surgery in health care systems. There is an association between being frail and developing greater delirium and/or postoperative cognitive deficit, which in summary translates into an increase in perioperative morbidity and mortality. For the prevention of POD, there are pharmacological and non-pharmacological measures that seek to promote orientation with respect to their environment and make it as familiar as possible, stimulate early aspects of memory and thinking skills, as well as promote sleep using environmental hygiene measures. In Chile, protocols of non-pharmacological measures have been proposed by occupational therapy teams, which have had positive results in reducing POD in frail elderly patients. These measures are temporal-spatial reorientation, physical mobilization, correction of sensory deficits, environmental management, sleep protocol, and reduction of anticholinergic drugs with statistically significant results in the reduction of POD. In accordance with the above, the objective of this study is to evaluate the impact of non-pharmacological measures applied by the nursing team in reducing the incidence of POD during the post-surgical period in fragile and pre-fragile EP undergoing elective non-cardiac surgeries. It is expected that in the end, frail and pre-frail EP who receive non-pharmacological interventions by the nursing team will present a lower incidence of POD at 24 hours compared to those who receive traditional care.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Pontificia Universidad Catolica de Chile","enrollment":400,"countries":["Chile"],"start_date":"2024-04-01","completion_date":"2026-12-31","last_update_date":"2025-06-10","source_url":"https://clinicaltrials.gov/study/NCT05993754","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"NPPOD","age_range":"65 Years","comparator":"Control group","organization":"Pontificia Universidad Catolica de Chile","interventions":["Non-pharmacological intervention"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Postoperative delirum (POD) — : 10 minutes, 60 minutes, 120 minutes, 720 minutes and 1440 minutes after anesthesia","Frailty _FRAIL — Pre Anesthesia period at same day of the surgery","Frailty_CFS — Pre Anesthesia period at same day of the surgery","Screening of Cognitive impairment_MiniCog — Pre Anesthesia period at same day of the surgery","Possible Cognitive impairment_MoCA — Pre Anesthesia period at same day of the surgery","Risk of anesthesia — Pre Anesthesia period at same day of the surgery","Type of surgery — Pre Anesthesia period at same day of the surgery","Educational level of chile — Pre Anesthesia period at same day of the surgery","Type of Anesthesia — Up to 30 minutes after the end of the surgery","Electroencephalogram monitoring during the anesthesia — Up to 30 minutes after the end of the surgery","Type of drugs during anesthesia — Up to 30 minutes after the end of the surgery","Postoperative Pain — 10 minutes, 60 minutes, 120 minutes, 720 minutes and 1440 minutes after anesthesia","Positive POD Positive CAM: presence of post-operative delirium (POD) Negative CAM:. absence of postoperative delirium (…"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Frail Elderly Syndrome","Primary Prevention","Postoperative Delirium","Frailty","Non-pharmacological intervention"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct05993754","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-04-01 to 2026-12-31","comparator":"Control group","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.506Z","intervention":["Non-pharmacological intervention"],"participants":400,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Postoperative delirum (POD) — : 10 minutes, 60 minutes, 120 minutes, 720 minutes and 1440 minutes after anesthesia","Frailty _FRAIL — Pre Anesthesia period at same day of the surgery","Frailty_CFS — Pre Anesthesia period at same day of the surgery","Screening of Cognitive impairment_MiniCog — Pre Anesthesia period at same day of the surgery","Possible Cognitive impairment_MoCA — Pre Anesthesia period at same day of the surgery","Risk of anesthesia — Pre Anesthesia period at same day of the surgery","Type of surgery — Pre Anesthesia period at same day of the surgery","Educational level of chile — Pre Anesthesia period at same day of the surgery","Type of Anesthesia — Up to 30 minutes after the end of the surgery","Electroencephalogram monitoring during the anesthesia — Up to 30 minutes after the end of the surgery","Type of drugs during anesthesia — Up to 30 minutes after the end of the surgery","Postoperative Pain — 10 minutes, 60 minutes, 120 minutes, 720 minutes and 1440 minutes after anesthesia","Positive POD Positive CAM: presence of post-operative delirium (POD) Negative CAM:. absence of postoperative delirium (…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31394","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}