{"type":"trials","record":{"id":31456,"source_id":"clinicaltrials-gov","external_id":"NCT00766584","title":"Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea","brief_summary":"The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity. Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population. It is even associated with sleep apnea/hypopnea.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Centre Hospitalier Universitaire de Saint Etienne","enrollment":852,"countries":["France"],"start_date":"2003-01-15","completion_date":"2026-12-01","last_update_date":"2025-03-18","source_url":"https://clinicaltrials.gov/study/NCT00766584","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:00:59.325+00:00","metadata":{"sex":"ALL","acronym":"SYNAPSE","age_range":"67 Years to 68 Years","comparator":null,"organization":"Centre Hospitalier Universitaire de Saint Etienne","interventions":["Sleep apnea/hypopnea detection"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Composite criterion : fatal and non-fatal cardiovascular or cerebrovascular events — During all the study","Presence and relationship of sleep apnea/hypopnea and clinically silent stroke revealed through brain MRI — Years 1, 3,…"],"design_description":null,"source_has_results":false},"controlled_terms":["Healthy","Sleep apnea/hypopnea detection"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T06:01:10.468881+00:00","duplicate_cluster_key":"id:nct00766584","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2003-01-15 to 2026-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 67 Years to 68 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:59.372Z","intervention":["Sleep apnea/hypopnea detection"],"participants":852,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Composite criterion : fatal and non-fatal cardiovascular or cerebrovascular events — During all the study","Presence and relationship of sleep apnea/hypopnea and clinically silent stroke revealed through brain MRI — Years 1, 3,…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Source terminology contains: sleep.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31456","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}