{"type":"trials","record":{"id":31473,"source_id":"clinicaltrials-gov","external_id":"NCT05455229","title":"Elucidating How Physical Activity and Sleep Relate to Optimal Cognitive Ageing","brief_summary":"Increased longevity is one of the greatest success stories in public health. However, ageing is accompanied by cognitive decline which affects people's daily functioning and, if it develops to dementia, their ability to live independently. By 2050, the number of people who develop dementia will triple to 152 million. The aim of this project is to precisely examine how physical activity (PA) and sleep, both modifiable lifestyle factors, are related to cognitive function and which role they can play in optimal cognitive ageing. To do so, a longitudinal study will be conducted, with objective measures of PA, sleep and cognition in midlife and older adults. This project will meet the current need for longitudinal studies with objective PA and sleep data, as well as provide, for the first time, in-depth information on associations of type of PA (aerobic vs muscle strengthening), characteristics of sleep (quality vs quantity) with specific cognitive domains (executive function and memory). Furthermore, although PA and sleep are related, the behavioural dynamics of combinations of PA and sleep on cognition has never been studied before. To fill this gap, these relationships will be examined with an innovative statistical approach, looking at data across a 24-hour period. The resulting deeper understanding of the precise relationship between PA, sleep and cognitive function will contribute to the development of preventive interventions for maintaining cognitive health at older age.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"KU Leuven","enrollment":260,"countries":["Belgium"],"start_date":"2021-07-22","completion_date":"2024-03-31","last_update_date":"2025-02-13","source_url":"https://clinicaltrials.gov/study/NCT05455229","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":"PASOCA","age_range":"55 Years","comparator":null,"organization":"KU Leuven","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Cognitive function (baseline) - objective: executive function and memory will be tested with Cambridge Neuropsychologic…","Change in cognitive function (follow up 1) - objective: executive function and memory will be tested with Cambridge Neu…","Change in cognitive function (follow up 2) - objective: executive function and memory will be tested with Cambridge Neu…","Cognitive function (baseline) - subjective: Cognitive Failure Questionnaire — baseline","Change in cognitive function (follow up 1) - subjective: Cognitive Failure Questionnaire — 1 year after baseline","Change in cognitive function (follow up 2) - subjective: Cognitive Failure Questionnaire — 1 year after follow up 1; 2…","Sleep (baseline) - objective: accelerometery - characteristic 1: total sleep time — baseline","Sleep (baseline) - objective: accelerometery - characteristic 2: wake after sleep onset — baseline","Sleep (baseline) - objective: accelerometery - characteristic 3: sleep efficiency — baseline","Sleep (baseline) - objective: accelerometery - characteristic 4: sleep latency — baseline","Change in sleep (follow up 1) - objective: accelerometery - characteristic 1: total sleep time — 1 year after baseline","Change in sleep (follow up 1) - objective: accelerometery - characteristic 2: wake after sleep onset — 1 year after bas…","Change in sleep (follow up 1) - objective: accelerometery - characteristic 3: sleep efficiency — 1 year after baseline","Change in sleep (follow up 1) - objective: accelerometery - characteristic 4: sleep latency — 1 year after baseline","Change in sleep (follow up 2) - objective: accelerometery - characteristic 1: total sleep time — 1 year after follow up…","Change in sleep (follow up 2) - objective: accelerometery - characteristic 2: wake after — 1 year after follow up 1; 2…","Change in sleep (follow up 2) - objective: accelerometery - characteristic 3: sleep efficiency — 1 year after follow up…","Change in sleep (follow up 2) - objective: accelerometery - characteristic 4: sleep latency — 1 year after follow up 1;…","Sleep (baseline) - subjective: Pittsburgh Sleep Quality Index (PSQI) — Baseline","Change in sleep (follow up 1) - subjective: Pittsburgh Sleep Quality Index (PSQI) — 1 year after baseline"],"design_description":null,"source_has_results":false},"controlled_terms":["Cognitive Aging"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: cognitive ageing.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct05455229","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-07-22 to 2024-03-31","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.904Z","intervention":[],"participants":260,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Cognitive function (baseline) - objective: executive function and memory will be tested with Cambridge Neuropsychologic…","Change in cognitive function (follow up 1) - objective: executive function and memory will be tested with Cambridge Neu…","Change in cognitive function (follow up 2) - objective: executive function and memory will be tested with Cambridge Neu…","Cognitive function (baseline) - subjective: Cognitive Failure Questionnaire — baseline","Change in cognitive function (follow up 1) - subjective: Cognitive Failure Questionnaire — 1 year after baseline","Change in cognitive function (follow up 2) - subjective: Cognitive Failure Questionnaire — 1 year after follow up 1; 2…","Sleep (baseline) - objective: accelerometery - characteristic 1: total sleep time — baseline","Sleep (baseline) - objective: accelerometery - characteristic 2: wake after sleep onset — baseline","Sleep (baseline) - objective: accelerometery - characteristic 3: sleep efficiency — baseline","Sleep (baseline) - objective: accelerometery - characteristic 4: sleep latency — baseline","Change in sleep (follow up 1) - objective: accelerometery - characteristic 1: total sleep time — 1 year after baseline","Change in sleep (follow up 1) - objective: accelerometery - characteristic 2: wake after sleep onset — 1 year after bas…","Change in sleep (follow up 1) - objective: accelerometery - characteristic 3: sleep efficiency — 1 year after baseline","Change in sleep (follow up 1) - objective: accelerometery - characteristic 4: sleep latency — 1 year after baseline","Change in sleep (follow up 2) - objective: accelerometery - characteristic 1: total sleep time — 1 year after follow up…","Change in sleep (follow up 2) - objective: accelerometery - characteristic 2: wake after — 1 year after follow up 1; 2…","Change in sleep (follow up 2) - objective: accelerometery - characteristic 3: sleep efficiency — 1 year after follow up…","Change in sleep (follow up 2) - objective: accelerometery - characteristic 4: sleep latency — 1 year after follow up 1;…","Sleep (baseline) - subjective: Pittsburgh Sleep Quality Index (PSQI) — Baseline","Change in sleep (follow up 1) - subjective: Pittsburgh Sleep Quality Index (PSQI) — 1 year after baseline"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: cognitive ageing.","Abstract contains controlled term: cognitive ageing.","Source terminology contains: cognitive aging.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}},{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31473","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}