{"type":"trials","record":{"id":31534,"source_id":"clinicaltrials-gov","external_id":"NCT06666660","title":"Daily Intake of Multivitamin & Mineral Supplementation Effects on Biological Age of Relatively Healthy Middle-aged Individuals","brief_summary":"Micronutrients, such as vitamins and minerals, are required to sustain fundamental physiological processes in individuals. As individuals age, the risk of having suboptimal levels of micronutrients increases due to several age-related changes affecting their digestion and assimilation processes. Suboptimal levels of micronutrients have been associated with increased risk of chronic diseases and accelerated ageing. Three years intake of a multivitamin and mineral supplement (MVM) improved global cognition, episodic memory and executive function in older adults. Furthermore, suboptimal micronutrient levels have been associated with a higher biological age, and diet and lifestyle interventions might lower the biological age measured by methylation clocks. Therefore, further evaluation is warranted to determine if MVM supplementation could improve the biological age and clinical outcomes in individuals with a higher biological age.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National University of Singapore","enrollment":400,"countries":["Singapore"],"start_date":"2024-09-23","completion_date":"2025-06-30","last_update_date":"2024-10-30","source_url":"https://clinicaltrials.gov/study/NCT06666660","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:15:13.984+00:00","metadata":{"sex":"ALL","acronym":"CEDIRA","age_range":"40 Years to 60 Years","comparator":"Placebo","organization":"National University of Singapore","interventions":["Multivitamin/Mineral supplements","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in blood DNA methylation status, years — Baseline, 6 months and 12 months","Body Mass Index (BMI) change — Baseline, 6 months and 12 months","Waist-to-hip ratio change — Baseline, 6 months and 12 months","Body fat mass (kg) change — Baseline, 6 months and 12 months","Skeletal muscle mass (kg) change — Baseline, 6 months and 12 months","Percentage body fat (%) change — Baseline, 6 months and 12 months","Systolic blood pressure (mm Hg) change — Baseline, 6 months and 12 months","Diastolic blood pressure (mm Hg) change — Baseline, 6 months and 12 months","Pulse rate (BPM) change — Baseline, 6 months and 12 months","Skin elasticity (mm/time) change — Baseline, 6 months and 12 months","Skin colour (L* a* b*) change — Baseline, 6 months and 12 months","Skin autofluorescence (au) change — Baseline, 6 months and 12 months","Complete blood count — Baseline, 6 months and 12 months","Change in immune parameters: complete blood count — Baseline, 6 months and 12 months","Change in immune parameters: inflammatory parameters in serum (mg/dL) — Baseline, 6 months, 12 months","Change in clinical blood parameters: renal function (mg/dL) — Baseline, 6 months and 12 months","Change in clinical blood parameters: lipid profile test (mmol/L) — Baseline, 6 months and 12 months","Change in clinical blood parameters: glucose (mg/dL) — Baseline, 6 months and 12 months","Change in clinical blood parameters: insulin (mg/dL) — Baseline, 6 months and 12 months","Change in clinical blood parameters: glycelated haemoglobin, HbA1C (mmol/mol) — Baseline, 6 months and 12 months"],"design_description":"RANDOMIZED · PARALLEL · HEALTH SERVICES RESEARCH · DOUBLE","source_has_results":false},"controlled_terms":["Relatively Healthy Volunteers","Multivitamin/Mineral supplements","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: biological age.","quality_checked_at":"2026-09-25T06:15:15.562724+00:00","duplicate_cluster_key":"id:nct06666660","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-23 to 2025-06-30","comparator":"Placebo","confidence":"structured-source","population":"ALL · 40 Years to 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:14.005Z","intervention":["Multivitamin/Mineral supplements","Placebo"],"participants":400,"study_design":"RANDOMIZED · PARALLEL · HEALTH SERVICES RESEARCH · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in blood DNA methylation status, years — Baseline, 6 months and 12 months","Body Mass Index (BMI) change — Baseline, 6 months and 12 months","Waist-to-hip ratio change — Baseline, 6 months and 12 months","Body fat mass (kg) change — Baseline, 6 months and 12 months","Skeletal muscle mass (kg) change — Baseline, 6 months and 12 months","Percentage body fat (%) change — Baseline, 6 months and 12 months","Systolic blood pressure (mm Hg) change — Baseline, 6 months and 12 months","Diastolic blood pressure (mm Hg) change — Baseline, 6 months and 12 months","Pulse rate (BPM) change — Baseline, 6 months and 12 months","Skin elasticity (mm/time) change — Baseline, 6 months and 12 months","Skin colour (L* a* b*) change — Baseline, 6 months and 12 months","Skin autofluorescence (au) change — Baseline, 6 months and 12 months","Complete blood count — Baseline, 6 months and 12 months","Change in immune parameters: complete blood count — Baseline, 6 months and 12 months","Change in immune parameters: inflammatory parameters in serum (mg/dL) — Baseline, 6 months, 12 months","Change in clinical blood parameters: renal function (mg/dL) — Baseline, 6 months and 12 months","Change in clinical blood parameters: lipid profile test (mmol/L) — Baseline, 6 months and 12 months","Change in clinical blood parameters: glucose (mg/dL) — Baseline, 6 months and 12 months","Change in clinical blood parameters: insulin (mg/dL) — Baseline, 6 months and 12 months","Change in clinical blood parameters: glycelated haemoglobin, HbA1C (mmol/mol) — Baseline, 6 months and 12 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"biological-age-biomarkers","is_published":true,"match_reasons":["Title contains controlled term: biological age.","Abstract contains controlled term: biological age.","Title supplies longevity context: biological age.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Biological age biomarkers","slug":"biological-age-biomarkers"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31534","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}