{"type":"trials","record":{"id":31559,"source_id":"clinicaltrials-gov","external_id":"NCT05744167","title":"Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle","brief_summary":"BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular properties and physical performance in healthy older men 60-75 years old.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Lithuanian Sports University","enrollment":60,"countries":["Lithuania"],"start_date":"2022-10-15","completion_date":"2023-11-17","last_update_date":"2024-09-03","source_url":"https://clinicaltrials.gov/study/NCT05744167","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:21.317971+00:00","last_seen_at":"2026-09-25T06:20:07.141+00:00","metadata":{"sex":"MALE","acronym":"BRAIN-M","age_range":"60 Years to 75 Years","comparator":"Control group","organization":"Lithuanian Sports University","interventions":["BFRT","MDRT"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in cognitive function on the Switching task (executive function) — Before first exercise bout, immediately after…","Change in cognitive function on the 2-Choice Reaction time (processing speed), Go/No-Go (inhibition) or 6 letter Memory…","Changes in lactate levels — Before first exercise bout, immediately after first exercise bout, 1 hour after the first e…","Changes in blood serum levels of TNFalpha and syndecan — Before first exercise bout, immediately after first exercise b…","Changes in blood plasma levels of BDNF — Before first exercise bout, immediately after first exercise bout, 1 hour afte…","Changes in blood serum levels of IGF-1, IL-6 and kynurenine — Before and after the 12 week intervention period","Changes in blood CK levels — Before first exercise bout and every 3 weeks for a total of 7 times 48 hours after the ecc…","Changes in muscle contractile characteristics (with tensiomyography (TMG)) — Before and after the 12 week intervention…","Changes in BMI — Before and after the 12 week intervention period","Changes in body fat % — Before and after the 12 week intervention period","Changes in SMI — Before and after the 12 week intervention period","Changes in fat free mass — Before and after the 12 week intervention period","Changes in patellar tendon crossectional area — Before and after the 12 week intervention period","Changes in patellar tendon stiffness — Before and after the 12 week intervention period","Changes in quadriceps muscle fascicle length — Before and after the 12 week intervention period","Changes in quadriceps muscle fascicle angle — Before and after the 12 week intervention period","Changes in quadriceps muscle thickness — Before and after the 12 week intervention period","Changes in quadriceps muscle cross-sectional area — Before and after the 12 week intervention period","Changes in quadriceps muscle fiber type — Before and after the 12 week intervention period","Changes in quadriceps muscle intramuscular fat — Before and after the 12 week intervention period"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Cognitive Decline","Sarcopenia","Frailty","Muscle Degeneration","Physical Disability","BFRT","MDRT"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:20:08.679024+00:00","duplicate_cluster_key":"id:nct05744167","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-10-15 to 2023-11-17","comparator":"Control group","confidence":"structured-source","population":"MALE · 60 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:07.160Z","intervention":["BFRT","MDRT"],"participants":60,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in cognitive function on the Switching task (executive function) — Before first exercise bout, immediately after…","Change in cognitive function on the 2-Choice Reaction time (processing speed), Go/No-Go (inhibition) or 6 letter Memory…","Changes in lactate levels — Before first exercise bout, immediately after first exercise bout, 1 hour after the first e…","Changes in blood serum levels of TNFalpha and syndecan — Before first exercise bout, immediately after first exercise b…","Changes in blood plasma levels of BDNF — Before first exercise bout, immediately after first exercise bout, 1 hour afte…","Changes in blood serum levels of IGF-1, IL-6 and kynurenine — Before and after the 12 week intervention period","Changes in blood CK levels — Before first exercise bout and every 3 weeks for a total of 7 times 48 hours after the ecc…","Changes in muscle contractile characteristics (with tensiomyography (TMG)) — Before and after the 12 week intervention…","Changes in BMI — Before and after the 12 week intervention period","Changes in body fat % — Before and after the 12 week intervention period","Changes in SMI — Before and after the 12 week intervention period","Changes in fat free mass — Before and after the 12 week intervention period","Changes in patellar tendon crossectional area — Before and after the 12 week intervention period","Changes in patellar tendon stiffness — Before and after the 12 week intervention period","Changes in quadriceps muscle fascicle length — Before and after the 12 week intervention period","Changes in quadriceps muscle fascicle angle — Before and after the 12 week intervention period","Changes in quadriceps muscle thickness — Before and after the 12 week intervention period","Changes in quadriceps muscle cross-sectional area — Before and after the 12 week intervention period","Changes in quadriceps muscle fiber type — Before and after the 12 week intervention period","Changes in quadriceps muscle intramuscular fat — Before and after the 12 week intervention period"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31559","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}