{"type":"trials","record":{"id":31890,"source_id":"clinicaltrials-gov","external_id":"NCT07440095","title":"Mortality Predictors in Patients 80+ After Major Abdominal Surgery: Role of Frailty and Physiological Reserve","brief_summary":"The aim of this study is to identify independent risk factors for 30-day mortality in patients aged 80 and over who have undergone major abdominal surgery. While traditional risk scoring systems often focus on chronic disease burden, they may not fully capture the biological decline associated with aging. This research specifically focuses on the predictive value of \"frailty\" and \"physiological reserve\" in determining surgical outcomes for this \"old-old\" patient population. In this retrospective cohort study, data from approximately 200 patients treated between 2022 and 2025 will be analyzed. Frailty will be assessed using the Modified Frailty Index (mFI-5), and physiological reserve will be evaluated through preoperative laboratory markers such as albumin, creatinine, and lymphocyte counts. By determining how these factors influence postoperative mortality, the study aims to improve preoperative patient selection, enhance risk communication with families, and provide a basis for protective strategies like prehabilitation.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","enrollment":100,"countries":["Turkey (Türkiye)"],"start_date":"2026-03-01","completion_date":"2026-04-10","last_update_date":"2026-04-30","source_url":"https://clinicaltrials.gov/study/NCT07440095","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"80 Years","comparator":null,"organization":"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","interventions":["Major Abdominal Surgery and Frailty Assessment"],"registry_source":"ClinicalTrials.gov","outcome_measures":["30-Day Postoperative Mortality — From the date of surgery up to 30 days postoperatively","Modified Frailty Index (mFI-5) Score — Preoperative assessment (retrospective data from 2022-2025)","Preoperative Serum Albumin Level — Preoperative laboratory values collected retrospectively from 2022-2025.","Preoperative Serum Creatinine Level — Preoperative laboratory values collected retrospectively from 2022-2025.","Preoperative Hemoglobin Level — Preoperative laboratory values collected retrospectively from 2022-2025"],"design_description":null,"source_has_results":false},"controlled_terms":["Frailty","Postoperative Complications","Aged, 80 and Over","Abdomen Cancer","Major Abdominal Surgery and Frailty Assessment"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07440095","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-03-01 to 2026-04-10","comparator":null,"confidence":"structured-source","population":"ALL · 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.440Z","intervention":["Major Abdominal Surgery and Frailty Assessment"],"participants":100,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["30-Day Postoperative Mortality — From the date of surgery up to 30 days postoperatively","Modified Frailty Index (mFI-5) Score — Preoperative assessment (retrospective data from 2022-2025)","Preoperative Serum Albumin Level — Preoperative laboratory values collected retrospectively from 2022-2025.","Preoperative Serum Creatinine Level — Preoperative laboratory values collected retrospectively from 2022-2025.","Preoperative Hemoglobin Level — Preoperative laboratory values collected retrospectively from 2022-2025"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty, frailty index.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31890","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}