{"type":"trials","record":{"id":31929,"source_id":"clinicaltrials-gov","external_id":"NCT03064503","title":"Myocardial Fibrosis, Function and Aging","brief_summary":"In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship between myocardial function changes, with local (T1 and diffusion) fibrosis measures with Magnetic Resonance Imaging (MRI) as well as global measures of fibrosis (skin auto-fluorescence and collagen blood-biomarkers).","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Hospices Civils de Lyon","enrollment":74,"countries":["France"],"start_date":"2017-02-20","completion_date":"2023-12-05","last_update_date":"2026-03-12","source_url":"https://clinicaltrials.gov/study/NCT03064503","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:15:20.281+00:00","metadata":{"sex":"ALL","acronym":"MARVEL","age_range":"18 Years","comparator":null,"organization":"Hospices Civils de Lyon","interventions":["Blood sampling","MRI","Skin auto-fluorescence"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Regional myocardial strain — The day of MRI","MRI T1 value — The day of MRI, before gadolinium injection","MRI T1 value — The day of MRI, 15 minutes after gadolinium injection","Apparent Diffusion Coefficient (ADC) with MRI — The day of MRI","Blood carboxy-terminal propeptide of procollagen type I (PICP) rate — The day of MRI","Blood amino-terminal propeptide of procollagen type III (PIIINP) rate — The day of MRI","Advanced Glycation End-products (AGE) rate — The day of MRI"],"design_description":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Healthy","Blood sampling","MRI","Skin auto-fluorescence"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: fibrosis.","quality_checked_at":"2026-09-25T06:15:30.843286+00:00","duplicate_cluster_key":"id:nct03064503","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-02-20 to 2023-12-05","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:20.322Z","intervention":["Blood sampling","MRI","Skin auto-fluorescence"],"participants":74,"study_design":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Regional myocardial strain — The day of MRI","MRI T1 value — The day of MRI, before gadolinium injection","MRI T1 value — The day of MRI, 15 minutes after gadolinium injection","Apparent Diffusion Coefficient (ADC) with MRI — The day of MRI","Blood carboxy-terminal propeptide of procollagen type I (PICP) rate — The day of MRI","Blood amino-terminal propeptide of procollagen type III (PIIINP) rate — The day of MRI","Advanced Glycation End-products (AGE) rate — The day of MRI"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"extracellular-matrix-aging","is_published":true,"match_reasons":["Title contains controlled term: fibrosis.","Abstract contains controlled term: fibrosis.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Extracellular matrix ageing","slug":"extracellular-matrix-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31929","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}