{"type":"trials","record":{"id":31998,"source_id":"clinicaltrials-gov","external_id":"NCT06294860","title":"Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy","brief_summary":"The primary objective of the study is to evaluate the epigenetic age in children with GH deficiency, before and after 6 months of treatment with growth hormone replacement therapy. The secondary objective is to correlate the epigenetic age with the auxometric and biochemical parameters used in the clinical-endocrinological practice. The results of the study will be useful to set up the clinical and biochemical follow-up of the hormone replacement therapy with rhGH and to understand the biomolecular mechanisms at the base of the debated \"anti\" or \"pro\" aging action of GH, the most important anabolic hormone of the human organism.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Istituto Auxologico Italiano","enrollment":10,"countries":["Italy"],"start_date":"2023-06-19","completion_date":"2025-03-30","last_update_date":"2025-09-03","source_url":"https://clinicaltrials.gov/study/NCT06294860","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:15:13.984+00:00","metadata":{"sex":"ALL","acronym":"ETABIOGHD","age_range":"5 Years to 15 Years","comparator":null,"organization":"Istituto Auxologico Italiano","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Measurement of biological (epigenetic) age — Baseline and after 6 months of substitutive treatment with recombinant gro…"],"design_description":null,"source_has_results":false},"controlled_terms":["Growth Hormone Deficiency","Short Stature"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: biological age.","quality_checked_at":"2026-09-25T06:15:15.562724+00:00","duplicate_cluster_key":"id:nct06294860","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-06-19 to 2025-03-30","comparator":null,"confidence":"structured-source","population":"ALL · 5 Years to 15 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:14.002Z","intervention":[],"participants":10,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Measurement of biological (epigenetic) age — Baseline and after 6 months of substitutive treatment with recombinant gro…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"biological-age-biomarkers","is_published":true,"match_reasons":["Title contains controlled term: biological age.","Title supplies longevity context: biological age.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Biological age biomarkers","slug":"biological-age-biomarkers"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/31998","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}