{"type":"trials","record":{"id":32082,"source_id":"clinicaltrials-gov","external_id":"NCT06430073","title":"Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAGEN)","brief_summary":"This prospective multicenter study aims at exploring the impact of infections on intra-hospital and 3-month changes in the frailty profile of older inpatients. To understand the complex pathways under the relationship between infections and frailty, this study will evaluate infection-related clinical and biochemical markers of systemic inflammation and genetics/epigenetics markers at ward admission. The interplay between clinical, functional, and genetics/epigenetics factors will be evaluated in a subgroup of patients by testing whether 3-month changes in frailty concur with changes in the genomic DNA markers. This study will help characterize the pathophysiological mechanisms of frailty and identify at-risk conditions that may accelerate its course.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University Hospital of Ferrara","enrollment":340,"countries":[],"start_date":"2024-05-20","completion_date":"2026-03-01","last_update_date":"2024-05-28","source_url":"https://clinicaltrials.gov/study/NCT06430073","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:15:13.984+00:00","metadata":{"sex":"ALL","acronym":"INFRAGEN","age_range":"70 Years","comparator":null,"organization":"University Hospital of Ferrara","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in frailty index from pre-admission to hospital discharge — From 14 days before admission to hospital discharge…","Change in Clinical Frailty Scale from pre-admission to hospital discharge — From 14 days before admission to hospital d…","Difference in in-hospital mortality between inpatients with vs without infections with systemic inflammation — From 14…","Difference in the length of hospital stay between inpatients with vs without infections with systemic inflammation — Fr…","Difference in the global DNA methylation between individuals with stable vs worsened frailty during the hospital stay.…","Difference in telomere length between individuals with stable vs worsened frailty during the hospital stay — From 14 da…","Change in frailty index from hospital discharge to 3-month follow-up — From hospital discharge until 3 months after hos…","Change in Clinical Frailty Scale from hospital discharge to 3-month follow-up — From hospital discharge until 3 months…"],"design_description":null,"source_has_results":false},"controlled_terms":["Aging","Frailty","Telomere Shortening","Inflammation","Hospital Infection"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: dna methylation.","quality_checked_at":"2026-09-25T06:15:15.562724+00:00","duplicate_cluster_key":"id:nct06430073","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-05-20 to 2026-03-01","comparator":null,"confidence":"structured-source","population":"ALL · 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:14.005Z","intervention":[],"participants":340,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in frailty index from pre-admission to hospital discharge — From 14 days before admission to hospital discharge…","Change in Clinical Frailty Scale from pre-admission to hospital discharge — From 14 days before admission to hospital d…","Difference in in-hospital mortality between inpatients with vs without infections with systemic inflammation — From 14…","Difference in the length of hospital stay between inpatients with vs without infections with systemic inflammation — Fr…","Difference in the global DNA methylation between individuals with stable vs worsened frailty during the hospital stay.…","Difference in telomere length between individuals with stable vs worsened frailty during the hospital stay — From 14 da…","Change in frailty index from hospital discharge to 3-month follow-up — From hospital discharge until 3 months after hos…","Change in Clinical Frailty Scale from hospital discharge to 3-month follow-up — From hospital discharge until 3 months…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"epigenetic-alterations","is_published":true,"match_reasons":["Title contains controlled term: dna methylation.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Epigenetic alterations","slug":"epigenetic-alterations"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32082","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}