{"type":"trials","record":{"id":32184,"source_id":"clinicaltrials-gov","external_id":"NCT03440099","title":"Sex-specific Adaptation to Resistance Training in Older Adults","brief_summary":"In general, men and women experience differing degrees of age-related decreases in physical function, with women having a greater prevalence of functional limitations and disability. A key predictor of this decrease in functional capacity is the reduction in leg muscle maximal power (product of force and velocity), which can be improved with exercise training. However, the development of exercise interventions to optimally improve skeletal muscle function in older adults has been difficult, in part because we now know that men and women respond differently to the same exercise training stimulus. In fact, the fundamental mechanisms by which habitual exercise improves physical function in older adults are still not well understood. The proposed studies are designed to address these knowledge gaps by examining the molecular and cellular mechanisms underlying the response to two distinct exercise training paradigms, and determining how these responses differ between older men and women. The investigators hypothesize that molecular, cellular and whole muscle contractile performance will be most improved in men by traditional low-velocity, high-load resistance training, and in women by high-velocity, low-load power training. Moreover, sex-specific structural responses in myofilament remodeling, protein expression and post-translational modifications will explain these sex-specific performance adaptations to each modality. To test these hypotheses, data will be gathered from 50 healthy, sedentary older men and women (65-75 years) prior to and following a 16-week unilateral exercise training program in which one leg undergoes resistance training and the other power training. The Specific Aims of this project are to identify the sex-specific effects of low-velocity resistance training versus high-velocity power training on: Aim 1) skeletal muscle function at the molecular, cellular and whole muscle levels, and Aim 2) protein expression and modification as well as size at the molecular and cellular levels. The within subject, unilateral intervention design provides a powerful model to minimize the effects of between-subject variability, and the translational approach will take advantage of our unique expertise with state-of-the-art measures from the molecular to whole body levels.","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Massachusetts, Amherst","enrollment":50,"countries":["United States"],"start_date":"2018-01-01","completion_date":"2024-03-31","last_update_date":"2022-06-28","source_url":"https://clinicaltrials.gov/study/NCT03440099","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:00:59.325+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 75 Years","comparator":null,"organization":"University of Massachusetts, Amherst","interventions":["Resistance exercise training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in peak isokinetic power — This measure will be collected for each volunteer pre- and post-16 week exercise inte…","Change in single fiber specific power — This measure will be preformed on tissue biopsied from each volunteer pre- and…","Change in myosin attachment time — This measure will be preformed on tissue biopsied from each volunteer pre- and post-…"],"design_description":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Biological Aging","Resistance exercise training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:01:10.468881+00:00","duplicate_cluster_key":"id:nct03440099","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-01-01 to 2024-03-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:59.393Z","intervention":["Resistance exercise training"],"participants":50,"study_design":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in peak isokinetic power — This measure will be collected for each volunteer pre- and post-16 week exercise inte…","Change in single fiber specific power — This measure will be preformed on tissue biopsied from each volunteer pre- and…","Change in myosin attachment time — This measure will be preformed on tissue biopsied from each volunteer pre- and post-…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32184","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}