{"type":"trials","record":{"id":32223,"source_id":"clinicaltrials-gov","external_id":"NCT04763525","title":"Efficacy of Pythagorean Self-Awareness for Aging Biomarkers Improvement, in T2D Patients and Healthy Individuals.","brief_summary":"The present study explored the effects of the implementation of the Pythagorean Self Awareness Intervention (PSAI) on the dynamics of stress-related aging factors of immune cells in healthy volunteers and a cohort patients with type 2 diabetes mellitus . The primary aim was to evaluate the effectiveness of PSAI on two key biomarkers of biological age, telomere length and proteasome levels, indicative of the crosstalk between cellular oxidative status and replicative potential, with respect to metabolic, hormonal and mental status changes. Secondary aims of this study included reduction of depression, perceived stress, anxiety and the establishment of lifestyle changes to enhance the quality of everyday life, including better quality of sleep, eating behaviours and an overall healthier status.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National and Kapodistrian University of Athens","enrollment":48,"countries":["Greece"],"start_date":"2018-10-04","completion_date":"2019-11-26","last_update_date":"2021-02-21","source_url":"https://clinicaltrials.gov/study/NCT04763525","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:15:13.984+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"19 Years","comparator":null,"organization":"National and Kapodistrian University of Athens","interventions":["Pythagorean Self-Awareness Intervention(PSAI)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Determination of telomeres' length — 2 months","Determination of telomeres' length — 6 months","Determination of 20S proteasome concentration — 6 months","Healthy Lifestyle and Personal Control Questionnaire — 6 months","Glycosylated haemoglobin — 6 months","Hair cortisol concentration — 6 months","Total Body Water — 6 months","Fat Free Mass — 6 months","Fat Mass — 6 months","Visceral fat — 6 months","Trunk fat — 6 months","Body Mass Index — 6 months","Depression Anxiety Stress Scale — 6 months","Perceived Stress Scale — 6 months","Self-referential quality of sleep — 6 months","Self-referential Internal Health Locus of Control — 6 months","Self-referential External and chance Health Locus of Control — 6 months","Self-referential health locus of control Powerful others — 6 months","Evaluation of verbal memory — 6 months","Evaluation of visuospatial memory — 6 months"],"design_description":"NON RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Type 2 Diabetes Mellitus","Telomere Shortening","Pythagorean Self-Awareness Intervention(PSAI)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: aging biomarker.","quality_checked_at":"2026-09-25T06:15:15.562724+00:00","duplicate_cluster_key":"id:nct04763525","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-10-04 to 2019-11-26","comparator":null,"confidence":"structured-source","population":"ALL · 19 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:14.010Z","intervention":["Pythagorean Self-Awareness Intervention(PSAI)"],"participants":48,"study_design":"NON RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Determination of telomeres' length — 2 months","Determination of telomeres' length — 6 months","Determination of 20S proteasome concentration — 6 months","Healthy Lifestyle and Personal Control Questionnaire — 6 months","Glycosylated haemoglobin — 6 months","Hair cortisol concentration — 6 months","Total Body Water — 6 months","Fat Free Mass — 6 months","Fat Mass — 6 months","Visceral fat — 6 months","Trunk fat — 6 months","Body Mass Index — 6 months","Depression Anxiety Stress Scale — 6 months","Perceived Stress Scale — 6 months","Self-referential quality of sleep — 6 months","Self-referential Internal Health Locus of Control — 6 months","Self-referential External and chance Health Locus of Control — 6 months","Self-referential health locus of control Powerful others — 6 months","Evaluation of verbal memory — 6 months","Evaluation of visuospatial memory — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"biological-age-biomarkers","is_published":true,"match_reasons":["Title contains controlled term: aging biomarker.","Abstract contains controlled term: biological age.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Biological age biomarkers","slug":"biological-age-biomarkers"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32223","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}