{"type":"trials","record":{"id":32233,"source_id":"clinicaltrials-gov","external_id":"NCT01953705","title":"n-3 PUFA for Vascular Cognitive Aging","brief_summary":"Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain function. This clinical trial will determine whether an omega 3 polyunsaturated fatty acid (PUFA) therapy can promote brain health by supporting the small blood vessels in the brain over 3 years in older adults at high risk for cognitive decline and dementia of Alzheimer's type.","overall_status":"Unknown","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Oregon Health and Science University","enrollment":102,"countries":["United States"],"start_date":"2014-05-01","completion_date":"2021-06-01","last_update_date":"2020-09-04","source_url":"https://clinicaltrials.gov/study/NCT01953705","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"75 Years","comparator":"Soybean oil","organization":"Oregon Health and Science University","interventions":["Omega 3 PUFA","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["total cerebral white matter hyperintensity volume — annual over 3 years","biomarkers of endothelial health — annual over 3 years","total brain atrophy — annual over 3 years","medial temporal lobe atrophy — annual over 3 years","ventricular expansion — annual over 3 years"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · QUADRUPLE","source_has_results":false},"controlled_terms":["Age Related Cognitive Decline","Alzheimer's Disease","Vascular Dementia","Endothelial Dysfunction","Executive Dysfunction","Omega 3 PUFA","Placebo"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: cognitive aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct01953705","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-05-01 to 2021-06-01","comparator":"Soybean oil","confidence":"structured-source","population":"ALL · 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.912Z","intervention":["Omega 3 PUFA","Placebo"],"participants":102,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["total cerebral white matter hyperintensity volume — annual over 3 years","biomarkers of endothelial health — annual over 3 years","total brain atrophy — annual over 3 years","medial temporal lobe atrophy — annual over 3 years","ventricular expansion — annual over 3 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: cognitive aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32233","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}