{"type":"trials","record":{"id":32297,"source_id":"clinicaltrials-gov","external_id":"NCT02876653","title":"Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.","brief_summary":"Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Assistance Publique - Hôpitaux de Paris","enrollment":53,"countries":["France"],"start_date":"2011-03-01","completion_date":"2014-01-01","last_update_date":"2016-08-24","source_url":"https://clinicaltrials.gov/study/NCT02876653","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"MALE","acronym":"SAOS","age_range":"20 Years to 65 Years","comparator":null,"organization":"Assistance Publique - Hôpitaux de Paris","interventions":["Polysomnography , blood collection, bone densitometry and Functional respiratory explorations"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Telomere length of circulating leukocytes — 4 weeks","Carotid-femoral pulse wave velocity — 4 weeks","Bone density — 4 weeks","Correlation between biological parameters and neuropsychological assessment — 4 weeks","Markers of oxidative stress: Malondialdehyde, heme oxygenase-1 — 4 weeks","Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1 — 4 weeks","Markers of growth hormone axis (GH, IGF-1, IGFBP) — 4 weeks"],"design_description":"NON RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Obstructive Sleep Apnea","Polysomnography , blood collection, bone densitometry and Functional respiratory explorations"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct02876653","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2011-03-01 to 2014-01-01","comparator":null,"confidence":"structured-source","population":"MALE · 20 Years to 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.496Z","intervention":["Polysomnography , blood collection, bone densitometry and Functional respiratory explorations"],"participants":53,"study_design":"NON RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Telomere length of circulating leukocytes — 4 weeks","Carotid-femoral pulse wave velocity — 4 weeks","Bone density — 4 weeks","Correlation between biological parameters and neuropsychological assessment — 4 weeks","Markers of oxidative stress: Malondialdehyde, heme oxygenase-1 — 4 weeks","Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1 — 4 weeks","Markers of growth hormone axis (GH, IGF-1, IGFBP) — 4 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Source terminology contains: sleep.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32297","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}