{"type":"trials","record":{"id":32307,"source_id":"clinicaltrials-gov","external_id":"NCT01345110","title":"A Longitudinal Multidimensional Population Study on Brain Aging","brief_summary":"Longitudinal observational study of cognitive functions, physical health and biological parameters in the whole population living in Abbiategrasso born between 1935 and 1939,1773 subjects, followed for six years in order to know the prevalence and the incidence of dementia and risk and protective factors of normal and pathological mental aging. The peculiarities of this study that must assure the outcome efficacy are: * Selected age: since 70-75 years old people represents a transition age from adulthood to old age, it is of special interest to study the evolution of psychic and physical functions of this population * Whole population not a sample study * Location: the small area involved (Abbiategrasso is a town of 30.000 inhabitants)can contribute to guarantee more homogeneity among the subjects and reduce undesired variability * multidimensional assessment(biological, clinical, social, psychological data collected) After initial screening, the recruited population will be followed up for two more times (every two years )","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Fondazione Golgi Cenci","enrollment":1321,"countries":["Italy"],"start_date":"2009-11-01","completion_date":"2015-12-01","last_update_date":"2015-12-11","source_url":"https://clinicaltrials.gov/study/NCT01345110","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":"InveCeAb","age_range":"70 Years to 75 Years","comparator":null,"organization":"Fondazione Golgi Cenci","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["The proportion of the recruited persons who will develop Dementia syndrome, Alzheimer disease, Vascular dementia, Lewy…","The proportion of persons who will exhibit a performance decrease equal or more than of 1,5 standard deviation of the m…","Neuropsychological baseline features of the persons who will develop dementia or cognitive impairment — six years","Clinical baseline features of the persons who will develop dementia or cognitive impairment — six years","Social baseline features of the persons who will developed dementia or cognitive impairment — six years","Genetic baseline features of the persons who will developed dementia and/or cognitive impairment — six years"],"design_description":null,"source_has_results":false},"controlled_terms":["Dementia","Alzheimer Disease","Vascular Dementia"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: brain aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct01345110","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2009-11-01 to 2015-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 70 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.916Z","intervention":[],"participants":1321,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["The proportion of the recruited persons who will develop Dementia syndrome, Alzheimer disease, Vascular dementia, Lewy…","The proportion of persons who will exhibit a performance decrease equal or more than of 1,5 standard deviation of the m…","Neuropsychological baseline features of the persons who will develop dementia or cognitive impairment — six years","Clinical baseline features of the persons who will develop dementia or cognitive impairment — six years","Social baseline features of the persons who will developed dementia or cognitive impairment — six years","Genetic baseline features of the persons who will developed dementia and/or cognitive impairment — six years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: brain aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32307","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}