{"type":"trials","record":{"id":32324,"source_id":"clinicaltrials-gov","external_id":"NCT01963221","title":"Relationship Between Thoracic Aortic Structure Assessed B PET/CT Scan and Arterial Stiffness in Elderly Patients","brief_summary":"The purpose of this study is to determine the relationship between thoracic aortic inflammation and arterial stiffness in elderly patients. Vascular-aging is accompanied by a gradual remodeling affecting both cardiac and arterial walls. Arterial hypertension, an established cardiovascular risk factor, has been suggested to exert pro-inflammatory actions threw several biological mediators enhancing arterial stiffness. Both effects of aging and hypertension are associated with higher levels of arterial stiffness, but their respective role is not well established in the pathophysiology of arterial stiffening. Few data are available neither on the real anatomic aortic impact of aging and hypertension on aortic compliance and ventricular function and its relationship to arterial stiffness assessed by carotid-femoral pulse wave velocity, nor on the reliability of cine phase contrast magnetic resonance imaging arterial stiffness measurements. Recent studies using positron emission tomography imaging (PET) with 18 F fluorodeoxyglucose (FDG) has been advocated as a means of measuring arterial wall inflammation in various population referred for oncology staging. FDG uptake is correlated with the number of cardiovascular risk factors and even the risk of future cardiovascular events. This method, combined with X-ray computed tomography (CT), has also demonstrated that aortic calcifications quantified by CT and local signs of inflammation detected by FDG uptake contribute to arterial stiffness. A strong relationship between large vessels stiffening assessed by carotid-femoral pulse wave velocity measurement, aortic calcifications quantified by CT and inflammation evaluated by FDG uptake has been demonstrated. Therefore, in the current study, we use FDG PET associated to CT to characterize aortic inflammation and aortic calcifications coupled to pulse wave velocity measurement and cardiac function in elderly individuals. In fact, if vascular aging promoting a local inflammatory process is a risk factor for cardiovascular disease, then vascular changes assessed by non-invasive vascular imaging (MRI,FDG PET) could represent a potential target for treatment and prevention Thirty individuals ≥ 65 years of age were examined, 15 hypertensive subjects and 15 controls. Pulse wave velocity, a surrogate for aortic stiffness, was measured both by cine phase contrast magnetic resonance imaging and applanation tonometry. Brachial pulse pressure, carotid calculated pulse pressure and pulse pressure amplification (brachial to carotid ratio), predictors of cardiovascular mortality were also quantified. Thoracic aorta local inflammation and calcification were measured by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography imaging. Moreover, biomarkers of low grade inflammation (high-sensitivity C-reactive protein, interleukin 6 were also determined).","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Central Hospital, Nancy, France","enrollment":30,"countries":["France"],"start_date":"2010-01-01","completion_date":"2013-09-01","last_update_date":"2013-10-16","source_url":"https://clinicaltrials.gov/study/NCT01963221","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:23.954312+00:00","last_seen_at":"2026-09-25T06:10:49.917+00:00","metadata":{"sex":"ALL","acronym":"FICTEP","age_range":"65 Years","comparator":null,"organization":"Central Hospital, Nancy, France","interventions":["fludeoxyglucose(18f)","blood sample","cardiac and aortic magnetic resonance imaging","carotid femoral pulse wave velocity","positron emission tomography","computed tomography"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Aortic inflammation assessed by 18 F FDG maximal standard uptake value measurement — one year","parietal thoracic aorta volume of calcification measured by computed tomography — one year"],"design_description":"NA · SINGLE GROUP · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["Aging","Inflammation","fludeoxyglucose(18f)","blood sample","cardiac and aortic magnetic resonance imaging","carotid femoral pulse wave velocity","positron emission tomography","computed tomography"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: arterial stiffness.","quality_checked_at":"2026-09-25T06:10:57.79658+00:00","duplicate_cluster_key":"id:nct01963221","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2010-01-01 to 2013-09-01","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:49.958Z","intervention":["fludeoxyglucose(18f)","blood sample","cardiac and aortic magnetic resonance imaging","carotid femoral pulse wave velocity","positron emission tomography","computed tomography"],"participants":30,"study_design":"NA · SINGLE GROUP · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Aortic inflammation assessed by 18 F FDG maximal standard uptake value measurement — one year","parietal thoracic aorta volume of calcification measured by computed tomography — one year"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: arterial stiffness.","Abstract contains controlled term: vascular aging, arterial stiffness.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32324","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}