{"type":"trials","record":{"id":32430,"source_id":"clinicaltrials-gov","external_id":"NCT07473037","title":"Efficacy of a Combined Oral and Topical Collagen Regimen Compared to Topical Collagen or Oral Collagen Regimens in Women With Skin Ageing Signs","brief_summary":"This clinical study is conducted at one study site and in 165 women with visible signs of skin aging. It compares after 13 weeks the benefit of a combined oral collagen supplement and topical collagen serum regimen compared with oral collagen alone and topical collagen serum alone in reducing in women presenting visible signs of skin ageing .","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Vichy Laboratoires","enrollment":165,"countries":[],"start_date":"2026-03-15","completion_date":"2026-10-31","last_update_date":"2026-03-16","source_url":"https://clinicaltrials.gov/study/NCT07473037","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"45 Years to 60 Years","comparator":"Group 2: Oral collagen supplement alone; Group 3: Topical collagen serum alone","organization":"Vichy Laboratoires","interventions":["Oral collagen","topical application of collagen serum"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Crow's feet score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 6=very deep severe wri…","Forhead wrinkle score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 5=very deep/severe…","Glabellar's wrinkle score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 5=very deep/se…","Underneath eye wrinkle score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 5=very deep…","Nasolabial fold score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no fold to 5=very deep/severe fol…","Upper lip wrinkle score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 6=very deep/seve…","Wrinkles of the corner of the lip score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to…","Ptosis of the lower part of the face on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 5=v…","Whole face wrinkles on a scale from 0=no visible wrinkle to 9= very visible wrinkle (clinical visual evaluation by the…","Skin firmness on a scale from 0=very firm skin to 9= very saggy/not firm skin (clinical tactile evaluation by the inves…","Skin elasticity on a scale from 0=very elastic skin to 9= very loose/not elastic skin (clinical tactile evaluation by t…","Skin tone eveness on a scale from 0=very even skin tone to 9= very even skin tone (clinical visual evaluation by the in…","Skin radiance on a scale from 0=very radiant complexion to 9= uneven complexion/ dull complexion (clinical visual evalu…","Skin smoothness on a scale from 0=very smooth skin texture, 9=very rough skin texture (clinical visual evaluation by th…","Skin density on a scale from0 = very low density, 9 = very high density (clinical tactile evaluation by the investigato…","Assessment of the mechanical properties of the skin by measuring its elasticity, firmness, and viscoelasticity using a…","Creating an imprint of a specific shape on the skin using a Dermotrac®. Its handle houses a spring-loaded piston that a…","Dermis density using SIAscope (Spectophotometric intracutaneous analysis; arbitrary units) — baseline, week 3, week 7,…","Image acquisition: LC-OCT Acquisition — baseline, week 3, week 7, week 13","Image acquisition: Selfies acquisition — baseline, week 3, week 7, week 13"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Visible Skin Aging Signs","Wrinkles and Folds in Lower Face","Skin Ageing","Skin Elasticity","Skin Firmness","Skin Evenness","Skin Radiance","Skin Smoothness","Skin Density","Oral collagen","topical application of collagen serum"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: skin ageing.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct07473037","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-03-15 to 2026-10-31","comparator":"Group 2: Oral collagen supplement alone; Group 3: Topical collagen serum alone","confidence":"structured-source","population":"FEMALE · 45 Years to 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.565Z","intervention":["Oral collagen","topical application of collagen serum"],"participants":165,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Crow's feet score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 6=very deep severe wri…","Forhead wrinkle score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 5=very deep/severe…","Glabellar's wrinkle score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 5=very deep/se…","Underneath eye wrinkle score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 5=very deep…","Nasolabial fold score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no fold to 5=very deep/severe fol…","Upper lip wrinkle score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 6=very deep/seve…","Wrinkles of the corner of the lip score on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to…","Ptosis of the lower part of the face on the L'Oreal Skin Atlas (Caucasian type) scale ranging from 0=no wrinkles to 5=v…","Whole face wrinkles on a scale from 0=no visible wrinkle to 9= very visible wrinkle (clinical visual evaluation by the…","Skin firmness on a scale from 0=very firm skin to 9= very saggy/not firm skin (clinical tactile evaluation by the inves…","Skin elasticity on a scale from 0=very elastic skin to 9= very loose/not elastic skin (clinical tactile evaluation by t…","Skin tone eveness on a scale from 0=very even skin tone to 9= very even skin tone (clinical visual evaluation by the in…","Skin radiance on a scale from 0=very radiant complexion to 9= uneven complexion/ dull complexion (clinical visual evalu…","Skin smoothness on a scale from 0=very smooth skin texture, 9=very rough skin texture (clinical visual evaluation by th…","Skin density on a scale from0 = very low density, 9 = very high density (clinical tactile evaluation by the investigato…","Assessment of the mechanical properties of the skin by measuring its elasticity, firmness, and viscoelasticity using a…","Creating an imprint of a specific shape on the skin using a Dermotrac®. Its handle houses a spring-loaded piston that a…","Dermis density using SIAscope (Spectophotometric intracutaneous analysis; arbitrary units) — baseline, week 3, week 7,…","Image acquisition: LC-OCT Acquisition — baseline, week 3, week 7, week 13","Image acquisition: Selfies acquisition — baseline, week 3, week 7, week 13"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin ageing.","Abstract contains controlled term: skin aging, skin ageing.","Source terminology contains: skin aging, skin ageing.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32430","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}