{"type":"trials","record":{"id":32448,"source_id":"clinicaltrials-gov","external_id":"NCT03678831","title":"Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and Osteoporosis","brief_summary":"Obesity and other associated complications promote the development and the progression of osteoarthritis. The subcutaneous and abdominal fat release several factors that alter bone and the cartilage. The role of the marrow fat in close connection with bone has not been defined yet, whereas cellular and animal models indicate that this fat depot modifies bone and cartilage. The aim of the study is to define if the marrow fat produces more joint-altering factors by comparison with subcutaneous fat. This fat depot can be characterized from removed pieces during the prosthetic surgery of the knee. Measuring before surgery the body weight, waist and hip circumferences, blood pressure, glucose, insulin and lipids in blood will also allow to determine if obesity and/or type 2 diabetes make this fat more dangerous for the joint. Such research will allow the elaboration of new therapeutic strategies in osteoarthritis.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University Hospital, Lille","enrollment":45,"countries":["France"],"start_date":"2020-06-30","completion_date":"2024-03-11","last_update_date":"2025-12-05","source_url":"https://clinicaltrials.gov/study/NCT03678831","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:20:19.667+00:00","metadata":{"sex":"FEMALE","acronym":"MEDADIPO","age_range":"18 Years to 85 Years","comparator":null,"organization":"University Hospital, Lille","interventions":["tissue"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Expression levels in femoral spinal adipocytes of mRNAs of 18 genes compared to those of adipocytes isolated from the s…","the intra patients difference of the expression level of medullary adipocytes mRNA compared to that of subcutaneous adi…"],"design_description":null,"source_has_results":false},"controlled_terms":["Osteoarthritis, Knee","Prosthesis User","tissue"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: osteoarthritis.","quality_checked_at":"2026-09-25T06:20:27.00315+00:00","duplicate_cluster_key":"id:nct03678831","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-06-30 to 2024-03-11","comparator":null,"confidence":"structured-source","population":"FEMALE · 18 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:19.697Z","intervention":["tissue"],"participants":45,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Expression levels in femoral spinal adipocytes of mRNAs of 18 genes compared to those of adipocytes isolated from the s…","the intra patients difference of the expression level of medullary adipocytes mRNA compared to that of subcutaneous adi…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"bone-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoporosis.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Bone ageing","slug":"bone-aging"}},{"topic_slug":"joint-cartilage-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoarthritis.","Abstract contains controlled term: osteoarthritis.","Source terminology contains: osteoarthritis.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Joint and cartilage ageing","slug":"joint-cartilage-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32448","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}