{"type":"trials","record":{"id":32485,"source_id":"clinicaltrials-gov","external_id":"NCT02525198","title":"The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial","brief_summary":"There is a dearth of research which takes a multi-compound approach to dietary interventions, in humans, aimed at improving outcome measures of cognition. Animal research in particular points towards fatty acids and flavonoids having a potentiating effect on each other, and possibly even being synergistic. Thus, study products will be administered in the present trial comprising both of these compounds, with a view to investigating their potential effects on cognition in older adults with mild cognitive impairment (MCI) or subjective memory impairment (SMI).","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of East Anglia","enrollment":259,"countries":["United States","Australia","United Kingdom"],"start_date":"2015-08-01","completion_date":"2018-03-31","last_update_date":"2024-05-14","source_url":"https://clinicaltrials.gov/study/NCT02525198","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:20:09.878+00:00","metadata":{"sex":"ALL","acronym":"CANN","age_range":"55 Years","comparator":"Placebo","organization":"University of East Anglia","interventions":["fatty acid/flavonoid blend","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Number of false positive responses during the picture recognition task of the CDR Computerized Cognitive Assessment Sys…","Hippocampal volume — 12 months","Gut microflora speciation and metabolism — 12 months","Association between baseline APOE status and number of false positive responses during the picture recognition task of…","Circulating biomarkers of cognition — 12 months","Circulating biomarkers of cardiovascular health — 12 months","Language ability on the Boston Naming Test — 12 months","Visuospatial ability on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Figure Copy test…","Attention ability on the Digit Span task — 12 months","Executive function on the Trail Making Task — 12 months","Cerebrovascular blood flow — 12 months","Measurement of blood brain barrier permeability — 8 minutes"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","source_has_results":false},"controlled_terms":["Mild Cognitive Impairment","Subjective Memory Impairment","fatty acid/flavonoid blend","Placebo"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: cognitive ageing.","quality_checked_at":"2026-09-25T06:20:11.344357+00:00","duplicate_cluster_key":"id:nct02525198","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-08-01 to 2018-03-31","comparator":"Placebo","confidence":"structured-source","population":"ALL · 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:09.902Z","intervention":["fatty acid/flavonoid blend","Placebo"],"participants":259,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of false positive responses during the picture recognition task of the CDR Computerized Cognitive Assessment Sys…","Hippocampal volume — 12 months","Gut microflora speciation and metabolism — 12 months","Association between baseline APOE status and number of false positive responses during the picture recognition task of…","Circulating biomarkers of cognition — 12 months","Circulating biomarkers of cardiovascular health — 12 months","Language ability on the Boston Naming Test — 12 months","Visuospatial ability on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Figure Copy test…","Attention ability on the Digit Span task — 12 months","Executive function on the Trail Making Task — 12 months","Cerebrovascular blood flow — 12 months","Measurement of blood brain barrier permeability — 8 minutes"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: cognitive ageing.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32485","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}