{"type":"trials","record":{"id":32509,"source_id":"clinicaltrials-gov","external_id":"NCT03126539","title":"Effect of Topical Sulforaphane on Skin Fragility Seen in Skin Aging and With Ultraviolet Exposure","brief_summary":"This study aims to compare the expression of keratins before and after application of sulforaphane (SF) to determine whether this agent alters skin fragility seen in both intrinsic and extrinsic skin aging and UV light exposure.","overall_status":"Terminated","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Johns Hopkins University","enrollment":9,"countries":["United States"],"start_date":"2017-09-15","completion_date":"2019-01-18","last_update_date":"2023-06-29","source_url":"https://clinicaltrials.gov/study/NCT03126539","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"Johns Hopkins University","interventions":["Sulforaphane","Narrow-band Ultraviolet B exposure","4 mm skin punch biopsy"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Clinical Change Score for Mottled Hyperpigmentation — Clinical Change Score for Mottled Hyperpigmentation , up to 1 week","Gene Expression Changes as Assessed by Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) — Up to 6…","Gene Expression Changes as Assessed by Immunohistochemistry (IHC) — Up to 6 months"],"design_description":"RANDOMIZED · PARALLEL · OTHER · NONE","source_has_results":true},"controlled_terms":["Aging","Sulforaphane","Narrow-band Ultraviolet B exposure","4 mm skin punch biopsy"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct03126539","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-09-15 to 2019-01-18","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.587Z","intervention":["Sulforaphane","Narrow-band Ultraviolet B exposure","4 mm skin punch biopsy"],"participants":9,"study_design":"RANDOMIZED · PARALLEL · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Clinical Change Score for Mottled Hyperpigmentation — Clinical Change Score for Mottled Hyperpigmentation , up to 1 week","Gene Expression Changes as Assessed by Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) — Up to 6…","Gene Expression Changes as Assessed by Immunohistochemistry (IHC) — Up to 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32509","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}