{"type":"trials","record":{"id":32560,"source_id":"clinicaltrials-gov","external_id":"NCT04133649","title":"Evaluation of Safety and Tolerability of Libella Gene Therapy for the Treatment of Aging: AAV- hTERT","brief_summary":"Using gene therapy to express active telomerase (hTERT) in humans has the potential to treat many of the age related diseases, including Aging itself. This study will entail treating subjects with hTERT delivered via transduction using AAV. The goal is to extend the telomeres to prevent, delay, or even reverse Aging.","overall_status":"Unknown","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Libella Gene Therapeutics","enrollment":5,"countries":["Colombia"],"start_date":"2019-10-17","completion_date":"2021-01-01","last_update_date":"2019-12-10","source_url":"https://clinicaltrials.gov/study/NCT04133649","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:05:20.497+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"45 Years","comparator":null,"organization":"Libella Gene Therapeutics","interventions":["AAV-hTERT"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Incidence of adverse events — 12 months","hTERT expression and telomerase activity — 12 months"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Aging","AAV-hTERT"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: gene therapy.","quality_checked_at":"2026-09-25T06:05:21.960425+00:00","duplicate_cluster_key":"id:nct04133649","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-10-17 to 2021-01-01","comparator":null,"confidence":"structured-source","population":"ALL · 45 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:20.517Z","intervention":["AAV-hTERT"],"participants":5,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Incidence of adverse events — 12 months","hTERT expression and telomerase activity — 12 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"gene-therapy","is_published":true,"match_reasons":["Title contains controlled term: gene therapy.","Abstract contains controlled term: gene therapy.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Gene therapy","slug":"gene-therapy"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32560","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}