{"type":"trials","record":{"id":32564,"source_id":"clinicaltrials-gov","external_id":"NCT01902004","title":"Brain Aging and Treatment Response in Geriatric Depression","brief_summary":"The proposed project will evaluate the role of neuroimaging biomarkers of brain aging (i.e., neurodegenerative and vascular brain changes) and mild cognitive impairment in the patterns of treatment response to memantine combined with escitalopram compared to escitalopram and placebo.","overall_status":"Completed","phases":["PHASE4"],"study_type":"INTERVENTIONAL","sponsor":"University of California, Los Angeles","enrollment":115,"countries":["United States"],"start_date":"2013-10-01","completion_date":"2019-01-23","last_update_date":"2019-10-15","source_url":"https://clinicaltrials.gov/study/NCT01902004","editorial_summary":"A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Escitalopram and Memantine; Escitalopram and placebo","organization":"University of California, Los Angeles","interventions":["Escitalopram","Memantine","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Hamilton Depression Rating Scale — Measured at 3 months; 6 months and 12 months","Change in Montgomery Asberg Depression Rating Scale — Measured at 3 months; 6 months and 12 months","Change in Cognitive Domain Scores — Measured at 6 months and 12 months"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":true},"controlled_terms":["Mild Cognitive Impairment (MCI)","Depression","Escitalopram","Memantine","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: brain aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct01902004","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2013-10-01 to 2019-01-23","comparator":"Escitalopram and Memantine; Escitalopram and placebo","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.913Z","intervention":["Escitalopram","Memantine","Placebo"],"participants":115,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE4","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Hamilton Depression Rating Scale — Measured at 3 months; 6 months and 12 months","Change in Montgomery Asberg Depression Rating Scale — Measured at 3 months; 6 months and 12 months","Change in Cognitive Domain Scores — Measured at 6 months and 12 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: brain aging.","Abstract contains controlled term: brain aging.","Title supplies longevity context: aging, geriatric.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32564","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}