{"type":"trials","record":{"id":32574,"source_id":"clinicaltrials-gov","external_id":"NCT02906566","title":"Retinol on Human Skin Aging in East Asian Descent","brief_summary":"There has been increasing evidence for different rates of natural aging in humans and one of the best organs to study human aging is skin. Studies have demonstrated anti-aging effects of topical agents (such as creams, gels, lotions, or ointments) and one of them, retinol or vitamin A, was shown to decrease fine wrinkling in skin of older individuals. Additionally, studies of retinol in humans have largely occurred in white populations and so this study aims to focus on skin aging in individuals of East Asian descent as they represent a majority of the world population. This study aims to better characterize the molecular basis of rejuvenation effects and to potentially discover new topical agents with similar and/or more effective preservation of skin youthfulness.","overall_status":"Completed","phases":["PHASE4"],"study_type":"INTERVENTIONAL","sponsor":"Stanford University","enrollment":110,"countries":["United States"],"start_date":"2015-11-01","completion_date":"2018-03-09","last_update_date":"2019-04-16","source_url":"https://clinicaltrials.gov/study/NCT02906566","editorial_summary":"A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"18 Years to 75 Years","comparator":"Young Group Ages 18-25","organization":"Stanford University","interventions":["Retinol","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) — Week…","Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baselin…","Transepidermal Water Loss — Baseline; Week 12","Severity of Arm Skin Wrinkling — Baseline; Week 12","Elasticity on Arm Skin — Baseline; week 12","Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events — B…"],"design_description":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","source_has_results":true},"controlled_terms":["Intrinsic Aging of Skin","Retinol","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct02906566","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-11-01 to 2018-03-09","comparator":"Young Group Ages 18-25","confidence":"structured-source","population":"FEMALE · 18 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.599Z","intervention":["Retinol","Placebo"],"participants":110,"study_design":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE4","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) — Week…","Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baselin…","Transepidermal Water Loss — Baseline; Week 12","Severity of Arm Skin Wrinkling — Baseline; Week 12","Elasticity on Arm Skin — Baseline; week 12","Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events — B…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32574","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}