{"type":"trials","record":{"id":32598,"source_id":"clinicaltrials-gov","external_id":"NCT02442479","title":"Maximizing Mechanisms of Muscle Hypertrophy to Combat Sarcopenia in Older Adults","brief_summary":"Resistance training has shown the most promise among interventions aimed to combat aging muscle atrophy as it enhances strength, power, and mobility function, but induces varying degrees of skeletal muscle hypertrophy as the investigators demonstrated in the initial 5-year funding period of this award (2001-2006). In the subsequent 5-year funding period (2007-2012), the investigators built on this prior work by using a dose-response approach in older adults - ultimately to optimize the treatment of age-related muscle atrophy. The investigators tested four, long-term resistance training prescriptions in older (60-75 yr) women and men to determine which prescription maximizes mechanisms driving muscle regrowth. One of the innovations in this project was the use of a 4-wk pre-training program to reach a plateau in the early, non-muscle mass adaptations, thereby establishing a true baseline from which both mechanisms of measurable muscle hypertrophy and functional consequences of hypertrophy could be studied in a tightly integrated fashion without bias in the subsequent experimental period. A randomized design was used to test the overarching hypothesis that a novel program of mixed strength and power training would optimize the anabolic environment to promote muscle hypertrophy and robust gains in performance. This hypothesis was tested with three specific aims.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Alabama at Birmingham","enrollment":127,"countries":["United States"],"start_date":"2007-04-01","completion_date":"2013-03-01","last_update_date":"2016-04-25","source_url":"https://clinicaltrials.gov/study/NCT02442479","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:05:15.478+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years to 75 Years","comparator":"HHH3","organization":"University of Alabama at Birmingham","interventions":["resistance training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["muscle mass — Change from baseline at week 35","vastus lateralis muscle fiber size — Change from baseline at week 35","maximum strength — Change from baseline at week 35","maximum power — Change from baseline at week 35"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Aging","Muscular Atrophy","resistance training"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:05:18.114262+00:00","duplicate_cluster_key":"id:nct02442479","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2007-04-01 to 2013-03-01","comparator":"HHH3","confidence":"structured-source","population":"ALL · 60 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:15.516Z","intervention":["resistance training"],"participants":127,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["muscle mass — Change from baseline at week 35","vastus lateralis muscle fiber size — Change from baseline at week 35","maximum strength — Change from baseline at week 35","maximum power — Change from baseline at week 35"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32598","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}