{"type":"trials","record":{"id":32606,"source_id":"clinicaltrials-gov","external_id":"NCT02222649","title":"Evaluation of the High Dose Vitamin D3 Supplementation Effect and Influence of Polymorphism VDR Gene on Oxidative Stress and Inflammatory Process in Elderly","brief_summary":"A vitamin D3 high dose would act as an antioxidant and anti-inflammatory improving markers of oxidative stress and inflammation in the elderly. Seniors exhibiting polymorphism in the VDR gene would become non-responsive to supplementation.","overall_status":"Unknown","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Federal University of Paraíba","enrollment":40,"countries":["Brazil"],"start_date":"2014-07-01","completion_date":"2015-09-01","last_update_date":"2015-03-06","source_url":"https://clinicaltrials.gov/study/NCT02222649","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:02.68364+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"60 Years to 90 Years","comparator":"placebo group","organization":"Federal University of Paraíba","interventions":["Vitamin D3","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["number of elderly women with sufficient vitamin D levels — four weeks after the intervention","number of elderly who have reduced serum levels of High-Sensitivity C-Reactive Protein — four weeks after the intervent…","number of elderly who have reduced serum levels of Alpha 1 Acid Glycoprotein — four weeks after the intervention","number of elderly who have reduced plasma levels of malondialdehyde (MDA) — four weeks after the intervention","number of elderly that increased plasma antioxidant full capacity — four weeks after the intervention"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Disorder of Aging","Vitamin D3","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: oxidative stress.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct02222649","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-07-01 to 2015-09-01","comparator":"placebo group","confidence":"structured-source","population":"FEMALE · 60 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.500Z","intervention":["Vitamin D3","Placebo"],"participants":40,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["number of elderly women with sufficient vitamin D levels — four weeks after the intervention","number of elderly who have reduced serum levels of High-Sensitivity C-Reactive Protein — four weeks after the intervent…","number of elderly who have reduced serum levels of Alpha 1 Acid Glycoprotein — four weeks after the intervention","number of elderly who have reduced plasma levels of malondialdehyde (MDA) — four weeks after the intervention","number of elderly that increased plasma antioxidant full capacity — four weeks after the intervention"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oxidative-stress","is_published":true,"match_reasons":["Title contains controlled term: oxidative stress.","Abstract contains controlled term: oxidative stress.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oxidative stress","slug":"oxidative-stress"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32606","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}