{"type":"trials","record":{"id":32743,"source_id":"clinicaltrials-gov","external_id":"NCT05588479","title":"Pomegranate Extract and Inflammageing","brief_summary":"The growing ageing population has resulted in an increase in the prevalence of frailty, cognitive disorders and cardiovascular diseases, representing a major cause of disability in older adults. Inflammation has been suggested as a pivotal factor leading to these disorders and is exacerbated by obesity. Polyphenols are antioxidants and anti-inflammatory agents that have been previously linked to a decrease in inflammation and cardiometabolic risk factors and an improvement in physical and cognitive function, yet research remain limited and inconclusive. This study aims to assess the effect of daily pomegranate extract supplementation on inflammatory response, cognitive and physical function and cardiometabolic risk factors in older adults. Seventy-one normal weight and overweight participants (55-70 years) will be assigned to consume either pomegranate extract capsules or placebo capsules for 12 weeks. Anthropometric measures (weight, height, waist circumference and hip circumference), body composition, blood pressure and a fasted venous blood sample will be collected during each visit at baseline, week 6 \\& week 12. Participants will also undergo computerised cognitive tests and physical function tests. Inflammatory markers, telomerase activity, serum glucose and lipid levels will be analysed. Diet diaries will be collected 3 times (at baseline, week 6 \\& week 12) during the intervention. This study will help elucidate the effects of pomegranate supplementation and inform future longitudinal trials looking at the combination of antioxidants and other lifestyle factors (such as physical activity) on the promotion of well-being and healthy ageing.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Manchester Metropolitan University","enrollment":86,"countries":["United Kingdom"],"start_date":"2022-12-10","completion_date":"2024-06-30","last_update_date":"2025-01-20","source_url":"https://clinicaltrials.gov/study/NCT05588479","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:05.322505+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years to 70 Years","comparator":"Control","organization":"Manchester Metropolitan University","interventions":["Pomegranate extract","Control"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Interleukin-6 (IL-6) levels — Baseline, week 6 & week 12","CRP (C-reactive protein) levels — Baseline, week 6 & week 12","Interleukin 1 (IL-1) levels — Baseline, week 6 & week 12","Interleukin 2 (IL-2) levels — Baseline, week 6 & week 12","Insulin growth factor-1 (IGF-1) levels — Baseline, week 6 & week 12","Tumour necrosis factor (TNF-α) levels — Baseline, week 6 & week 12","Plasminogen Activator Inhibitor-1 (PAI-1) levels — Baseline, week 6 & week 12","Telomerase activity — Baseline, week 6 & week 12","Corsi block-tapping test — Baseline, week 6 & week 12","Rey Verbal Learning test — Baseline, week 6 & week 12","Tower of Hanoi test — Baseline, week 6 & week 12","Wisconsin test — Baseline, week 6 & week 12","Stroop test — Baseline, week 6 & week 12","Digits span test — Baseline, week 6 & week 12","Hand grip strength — Baseline, week 6 & week 12","Standing balance — Baseline, week 6 & week 12","Gait speed — Baseline, week 6 & week 12","Chair sit to stand — Baseline, week 6 & week 12","Fasting serum glucose levels — Baseline, week 6 & week 12","Fasting lipid levels — Baseline, week 6 & week 12"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Pomegranate extract","Control"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: inflammageing.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct05588479","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-12-10 to 2024-06-30","comparator":"Control","confidence":"structured-source","population":"ALL · 55 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.527Z","intervention":["Pomegranate extract","Control"],"participants":86,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Interleukin-6 (IL-6) levels — Baseline, week 6 & week 12","CRP (C-reactive protein) levels — Baseline, week 6 & week 12","Interleukin 1 (IL-1) levels — Baseline, week 6 & week 12","Interleukin 2 (IL-2) levels — Baseline, week 6 & week 12","Insulin growth factor-1 (IGF-1) levels — Baseline, week 6 & week 12","Tumour necrosis factor (TNF-α) levels — Baseline, week 6 & week 12","Plasminogen Activator Inhibitor-1 (PAI-1) levels — Baseline, week 6 & week 12","Telomerase activity — Baseline, week 6 & week 12","Corsi block-tapping test — Baseline, week 6 & week 12","Rey Verbal Learning test — Baseline, week 6 & week 12","Tower of Hanoi test — Baseline, week 6 & week 12","Wisconsin test — Baseline, week 6 & week 12","Stroop test — Baseline, week 6 & week 12","Digits span test — Baseline, week 6 & week 12","Hand grip strength — Baseline, week 6 & week 12","Standing balance — Baseline, week 6 & week 12","Gait speed — Baseline, week 6 & week 12","Chair sit to stand — Baseline, week 6 & week 12","Fasting serum glucose levels — Baseline, week 6 & week 12","Fasting lipid levels — Baseline, week 6 & week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"chronic-inflammation","is_published":true,"match_reasons":["Title contains controlled term: inflammageing.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Chronic inflammation","slug":"chronic-inflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32743","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}