{"type":"trials","record":{"id":32804,"source_id":"clinicaltrials-gov","external_id":"NCT04003935","title":"Juice Plus Inflammaging and Cardiovascular Disease Prevention Study","brief_summary":"Low- grade inflammation is a pathological feature of a wide range of chronic conditions, including the metabolic syndrome, cardiovascular diseases (CVD) and the accelerated reduction in bone density. Previous research shows that diets rich in fruits and vegetables can reduce chronic inflammation. To date there is no data on multiyear clinical interventions assessing the effect of plant-based dietary supplements on low-grade inflammation, cardiovascular disease prevention and indicators of biological aging, including individuals' cognitive function. In this study, the investigators are thus exploring whether separate ingestions of two plant-based nutritional products over 2 years, are able to modulate low-grade inflammation, parameters of CVD prevention, circulating micronutrients, upper respiratory tract- and gastro-intestinal symptoms, quality of life, indicators of biological aging, and cognitive function in overweight seniors.","overall_status":"Terminated","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Green Beat","enrollment":22,"countries":["Austria"],"start_date":"2019-06-01","completion_date":"2020-05-27","last_update_date":"2020-05-29","source_url":"https://clinicaltrials.gov/study/NCT04003935","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:05.322505+00:00","last_seen_at":"2026-09-25T06:05:37.656+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 80 Years","comparator":null,"organization":"Green Beat","interventions":["Juice Plus+ Complete","Juice Plus+ Premium"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Concentration changes in biomarkers of low-grade inflammation — 24 months","Plasma concentration changes in biomarkers of CVD — 24 months","Efficacy of micronutrients' absorption — 24 months","Wisconsin upper respiratory symptoms survey (WURSS) — 24 months","Gastrointestinal symptoms survey (GISS-14) — 24 months","Quality of life — 24 months","Body mass assessment — 24 months","Anthropometrics — 24 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Overweight or Obesity","Juice Plus+ Complete","Juice Plus+ Premium"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: inflammaging.","quality_checked_at":"2026-09-25T06:05:39.423355+00:00","duplicate_cluster_key":"id:nct04003935","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-06-01 to 2020-05-27","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:37.673Z","intervention":["Juice Plus+ Complete","Juice Plus+ Premium"],"participants":22,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Concentration changes in biomarkers of low-grade inflammation — 24 months","Plasma concentration changes in biomarkers of CVD — 24 months","Efficacy of micronutrients' absorption — 24 months","Wisconsin upper respiratory symptoms survey (WURSS) — 24 months","Gastrointestinal symptoms survey (GISS-14) — 24 months","Quality of life — 24 months","Body mass assessment — 24 months","Anthropometrics — 24 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"chronic-inflammation","is_published":true,"match_reasons":["Title contains controlled term: inflammaging.","Abstract contains controlled term: chronic inflammation.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Chronic inflammation","slug":"chronic-inflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32804","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}