{"type":"trials","record":{"id":32954,"source_id":"clinicaltrials-gov","external_id":"NCT06940037","title":"The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults","brief_summary":"To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Mayo Clinic","enrollment":300,"countries":["United States"],"start_date":"2025-08-11","completion_date":"2030-08-31","last_update_date":"2025-09-16","source_url":"https://clinicaltrials.gov/study/NCT06940037","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:06.962668+00:00","last_seen_at":"2026-09-25T06:05:22.821+00:00","metadata":{"sex":"ALL","acronym":"BRIO","age_range":"65 Years","comparator":null,"organization":"Mayo Clinic","interventions":["Progressive Resistance Training","Health Education"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Precisely define the variability in changes in physical function — baseline, 6 months","Precisely define the variability in changes in blood glucose concentrations in response to a meal tolerance test — base…","Precisely define the variability in changes in skeletal muscle size. — baseline, 6 months","Precisely define the variability in changes in skeletal muscle strength. — baseline, 6 months","Precisely define the variability in changes in six-minute walk distance. — baseline, 6 months","Precisely define the variability in insulin secretion in response to a mixed meal tolerance test. — baseline, 6 months","Precisely define the variability in changes in the percentage of glycated hemoglobin in the blood. — baseline, 6 months","Precisely define the variability in changes in blood lipids. — baseline, 6 months","Precisely define the variability in changes in waist-to-hip ratio. — baseline, 6 months"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Mobility Disability","Progressive Resistance Training","Health Education"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:05:25.247365+00:00","duplicate_cluster_key":"id:nct06940037","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-08-11 to 2030-08-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:22.839Z","intervention":["Progressive Resistance Training","Health Education"],"participants":300,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Precisely define the variability in changes in physical function — baseline, 6 months","Precisely define the variability in changes in blood glucose concentrations in response to a meal tolerance test — base…","Precisely define the variability in changes in skeletal muscle size. — baseline, 6 months","Precisely define the variability in changes in skeletal muscle strength. — baseline, 6 months","Precisely define the variability in changes in six-minute walk distance. — baseline, 6 months","Precisely define the variability in insulin secretion in response to a mixed meal tolerance test. — baseline, 6 months","Precisely define the variability in changes in the percentage of glycated hemoglobin in the blood. — baseline, 6 months","Precisely define the variability in changes in blood lipids. — baseline, 6 months","Precisely define the variability in changes in waist-to-hip ratio. — baseline, 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Source terminology contains: resistance training.","Title supplies longevity context: aging, older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/32954","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}