{"type":"trials","record":{"id":33030,"source_id":"clinicaltrials-gov","external_id":"NCT05813379","title":"Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation","brief_summary":"Aging is a natural and complex process. The effect of environmental factors, genetics on the body eventually leads to damage in different ways. Exosomes are present in almost all body fluids, such as synovial fluid and blood. Exosomes and microvesicles are very efficient mediators of cell-to-cell communication by transferring their specific cargo to recipient cells; for example, exosomes are involved in the delivery of genetic materials, causing epigenetic modifications in the target cells .The applications of MSC-derived exosomes have more effect in cutaneous regeneration by collagen stimulation.The basic biology of exosomes indicates that MSC-exosomes may contain MSC-specific components to exert specific effects on recipient cells, which are somewhat equivalent to the regenerative effects of MSCs. This study aims to slow down the aging process of the skin by using exosome.","overall_status":"Unknown","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Isfahan University of Medical Sciences","enrollment":20,"countries":["Iran"],"start_date":"2022-02-01","completion_date":"2023-08-30","last_update_date":"2023-04-14","source_url":"https://clinicaltrials.gov/study/NCT05813379","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:06.962668+00:00","last_seen_at":"2026-09-25T06:05:22.821+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"35 Years to 65 Years","comparator":null,"organization":"Isfahan University of Medical Sciences","interventions":["exosime injection"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Proportion of re-epithelialization — 1 month","Proportion of re-epithelialization — 3 months"],"design_description":"NA · SINGLE GROUP · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Anti Aging","exosime injection"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-25T06:05:25.247365+00:00","duplicate_cluster_key":"id:nct05813379","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-02-01 to 2023-08-30","comparator":null,"confidence":"structured-source","population":"FEMALE · 35 Years to 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:22.849Z","intervention":["exosime injection"],"participants":20,"study_design":"NA · SINGLE GROUP · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1, PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Proportion of re-epithelialization — 1 month","Proportion of re-epithelialization — 3 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Title supplies longevity context: rejuvenation.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/33030","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}