{"type":"trials","record":{"id":33047,"source_id":"clinicaltrials-gov","external_id":"NCT05510375","title":"Cocoa Supplementation, Inflammaging, and Epigenetic Aging","brief_summary":"The COcoa Supplement and Multivitamin Outcomes Study (COSMOS; NCT02422745) is a randomized clinical trial of cocoa extract supplement (containing a total of 500 mg/d flavanols, including 80 mg. (-)-epicatechins), and a standard multivitamin supplement to reduce the risk of cardiovascular disease and cancer among men aged 60 years and older and women aged 65 years and older. This ancillary study is being conducted among participants in COSMOS and will examine whether the cocoa extract supplement or the multivitamin supplement has an anti-aging effect (epigenetic aging and inflammaging) and examining these findings in the context of CVD risk factors and outcomes.","overall_status":"Unknown","phases":["PHASE4"],"study_type":"INTERVENTIONAL","sponsor":"Augusta University","enrollment":21442,"countries":[],"start_date":"2015-06-01","completion_date":"2023-09-30","last_update_date":"2022-08-22","source_url":"https://clinicaltrials.gov/study/NCT05510375","editorial_summary":"A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:06.962668+00:00","last_seen_at":"2026-09-25T06:05:37.656+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Cocoa extract + multivitamin; Cocoa extract + multivitamin placebo; Cocoa extract placebo + multivitamin; Cocoa extract placebo + multivitamin placebo","organization":"Augusta University","interventions":["Cocoa extract","Multivitamin","Cocoa extract placebo","Multivitamin placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Epigenetic age acceleration — 2 years","Inflammaging — 2 years","Blood pressure — 2 years","Body mass index — 2 years","Pulse wave velocity — 2 years"],"design_description":"RANDOMIZED · FACTORIAL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Inflammation","Cardiovascular Diseases","Cocoa extract","Multivitamin","Cocoa extract placebo","Multivitamin placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: inflammaging.","quality_checked_at":"2026-09-25T06:05:39.423355+00:00","duplicate_cluster_key":"id:nct05510375","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-06-01 to 2023-09-30","comparator":"Cocoa extract + multivitamin; Cocoa extract + multivitamin placebo; Cocoa extract placebo + multivitamin; Cocoa extract placebo + multivitamin placebo","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:37.670Z","intervention":["Cocoa extract","Multivitamin","Cocoa extract placebo","Multivitamin placebo"],"participants":21442,"study_design":"RANDOMIZED · FACTORIAL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE4","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Epigenetic age acceleration — 2 years","Inflammaging — 2 years","Blood pressure — 2 years","Body mass index — 2 years","Pulse wave velocity — 2 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"chronic-inflammation","is_published":true,"match_reasons":["Title contains controlled term: inflammaging.","Abstract contains controlled term: inflammaging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Chronic inflammation","slug":"chronic-inflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/33047","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}