{"type":"trials","record":{"id":33137,"source_id":"clinicaltrials-gov","external_id":"NCT02945774","title":"Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias","brief_summary":"Neuroinflammation is increasingly implicated as a potential critical pathogenic mechanism in a variety of neurologic and psychiatric disorders. This study will use hybrid PET/MRI imaging to evaluate neuroinflammation and its relationship to cerebral perfusion in frontotemporal dementia (FTD). Patients with FTD will be recruited from the Cognitive Neurology and Aging Brain clinics at Parkwood Institute and will undergo neurocognitive assessment and MRI/PET using the PET ligand FEPPA which binds to activated microglia, a marker of neuroinflammation. Correlations will be conducted to determine whether abnormal neuroinflammation is present in Frontotemporal dementia and whether differential patterns of neuroinflammation are present in different FTD clinical and molecular subtypes, and to determine the relationship between neuroinflammation, cerebral perfusion using arterial spin labeling MRI imaging techniques, and indices of brain structure including volumetric and white matter analysis.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","enrollment":40,"countries":["Canada"],"start_date":"2016-08-01","completion_date":"2029-08-01","last_update_date":"2025-03-05","source_url":"https://clinicaltrials.gov/study/NCT02945774","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:07.921608+00:00","last_seen_at":"2026-09-25T06:20:07.141+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"30 Years to 95 Years","comparator":null,"organization":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","interventions":["(18F)-FEPPA"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Group differences in regional PET FEPPA ligand imaging — 120 Minutes","Correlation between PET FEPPA ligand images and specified MR images — 120 Minutes"],"design_description":"NA · SINGLE GROUP · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["Frontotemporal Dementia","(18F)-FEPPA"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: neuroinflammation.","quality_checked_at":"2026-09-25T06:20:08.679024+00:00","duplicate_cluster_key":"id:nct02945774","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-08-01 to 2029-08-01","comparator":null,"confidence":"structured-source","population":"ALL · 30 Years to 95 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:07.159Z","intervention":["(18F)-FEPPA"],"participants":40,"study_design":"NA · SINGLE GROUP · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Group differences in regional PET FEPPA ligand imaging — 120 Minutes","Correlation between PET FEPPA ligand images and specified MR images — 120 Minutes"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"neuroinflammation","is_published":true,"match_reasons":["Title contains controlled term: neuroinflammation.","Abstract contains controlled term: neuroinflammation.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Neuroinflammation","slug":"neuroinflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/33137","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}