{"type":"trials","record":{"id":33305,"source_id":"clinicaltrials-gov","external_id":"NCT05828043","title":"Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline","brief_summary":"The primary goal is to develop a multidomain intervention program focused on preserving global or regional brain volume and functions while simultaneously improving physical mobility and cognitive functions in older individuals with mobility frailty. This initiative seeks to unravel the brain-muscle axis mechanisms contributing to the accelerated functional declines observed in older populations. Moreover, our objective includes examining the relationships between the intervention and a broad spectrum of clinical characteristics, phenotypic traits, biochemical profiles, myokines, proteomics, metabolomics, brain imaging, and our previously identified discoveries involving exosomal miRNA.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National Yang Ming Chiao Tung University","enrollment":102,"countries":["Taiwan"],"start_date":"2021-11-01","completion_date":"2023-07-30","last_update_date":"2023-12-26","source_url":"https://clinicaltrials.gov/study/NCT05828043","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:09.013623+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Usual care group","organization":"National Yang Ming Chiao Tung University","interventions":["Multi-domain intervention"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in brain structures on MRI — baseline, 12 month","Change in Physical performance — baseline, 6, 12 month","Life quality SF12 — baseline, 6, 12 month","Change in Complete blood count — baseline, 6, 12 month","Change in Nutrition intake — baseline, 6, 12 month","Change in depression — baseline, 6, 12 month","Change in cognitive ability — baseline, 6, 12 month","Change in International Physical Activity Questionnaire (IPAQ) — baseline, 6, 12 month","Change in Vitamin D3 25-OH — baseline, 6, 12 month","Change in DHEA-S — baseline, 6, 12 month","Change in IGF-1 — baseline, 6, 12 month","Change in Homocysteine — baseline, 6, 12 month","Change in hs-CRP — baseline, 6, 12 month","Change in Zinc — baseline, 6, 12 month","Change in TSH — baseline, 6, 12 month","Change in Myostatin — baseline, 6, 12 month","Change in Activing A — baseline, 6, 12 month","Change in Follistatin — baseline, 6, 12 month","Change in Relative appendicular skeletal muscle index (RASM) — baseline, 6, 12 month","Change in body fat % — baseline, 6, 12 month"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Age-related Cognitive Decline","Age-related Physiology Decline","Multi-domain intervention"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: brain aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct05828043","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-11-01 to 2023-07-30","comparator":"Usual care group","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.909Z","intervention":["Multi-domain intervention"],"participants":102,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in brain structures on MRI — baseline, 12 month","Change in Physical performance — baseline, 6, 12 month","Life quality SF12 — baseline, 6, 12 month","Change in Complete blood count — baseline, 6, 12 month","Change in Nutrition intake — baseline, 6, 12 month","Change in depression — baseline, 6, 12 month","Change in cognitive ability — baseline, 6, 12 month","Change in International Physical Activity Questionnaire (IPAQ) — baseline, 6, 12 month","Change in Vitamin D3 25-OH — baseline, 6, 12 month","Change in DHEA-S — baseline, 6, 12 month","Change in IGF-1 — baseline, 6, 12 month","Change in Homocysteine — baseline, 6, 12 month","Change in hs-CRP — baseline, 6, 12 month","Change in Zinc — baseline, 6, 12 month","Change in TSH — baseline, 6, 12 month","Change in Myostatin — baseline, 6, 12 month","Change in Activing A — baseline, 6, 12 month","Change in Follistatin — baseline, 6, 12 month","Change in Relative appendicular skeletal muscle index (RASM) — baseline, 6, 12 month","Change in body fat % — baseline, 6, 12 month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: brain aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/33305","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}