{"type":"trials","record":{"id":33326,"source_id":"clinicaltrials-gov","external_id":"NCT01898611","title":"Ghrelin Plus Strength Training in Frail Elderly Study","brief_summary":"Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. There are currently no approved therapies for frailty. Ghrelin is a hormone produced by the stomach that stimulates appetite centers in the brain. The investigators already know that a single dose of Ghrelin improves food intake immediately after the dose in frail older people. In addition, exercise programs have been shown to improve strength and function in older people. In this study, the investigators are trying to find out if a joint intervention of ghrelin and resistance training will improve walking, balance and leg strength in frail elderly people.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"University of Pennsylvania","enrollment":16,"countries":["United States"],"start_date":"2013-07-01","completion_date":"2016-08-31","last_update_date":"2019-12-11","source_url":"https://clinicaltrials.gov/study/NCT01898611","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:09.013623+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"70 Years","comparator":"Ghrelin plus resistance training; Placebo plus resistance training","organization":"University of Pennsylvania","interventions":["Ghrelin","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in the Short Physical Performance Battery (SPPB) — Baseline to 12 weeks","Treatment-associated Adverse Events — Twelve weeks","Change in Weight — Baseline to twelve weeks","Change in Lean Body Mass — Baseline to 12 weeks","Change in Muscle Strength — Baseline to 12 weeks","Change in Food Intake — Baseline to 12 weeks.","Change in Quality of Life — Baseline to 12 weeks.","Change in Frailty Status — Baseline to 12 weeks."],"design_description":"RANDOMIZED · PARALLEL · OTHER · QUADRUPLE","source_has_results":true},"controlled_terms":["Frailty Syndrome","Ghrelin","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct01898611","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2013-07-01 to 2016-08-31","comparator":"Ghrelin plus resistance training; Placebo plus resistance training","confidence":"structured-source","population":"ALL · 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.890Z","intervention":["Ghrelin","Placebo"],"participants":16,"study_design":"RANDOMIZED · PARALLEL · OTHER · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in the Short Physical Performance Battery (SPPB) — Baseline to 12 weeks","Treatment-associated Adverse Events — Twelve weeks","Change in Weight — Baseline to twelve weeks","Change in Lean Body Mass — Baseline to 12 weeks","Change in Muscle Strength — Baseline to 12 weeks","Change in Food Intake — Baseline to 12 weeks.","Change in Quality of Life — Baseline to 12 weeks.","Change in Frailty Status — Baseline to 12 weeks."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: resistance training.","Title supplies longevity context: frail, elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/33326","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}