{"type":"trials","record":{"id":33327,"source_id":"clinicaltrials-gov","external_id":"NCT04112875","title":"Effect of L-arginine on Microcirculation, Myogenesis and Angiogenesis Associated With Aging, Sarcopenia and Diabetes","brief_summary":"This study aims was evaluated the effect of L-arginine on microcirculation, vasoreactivity / endothelial function and vascular smooth muscle of young and old women with Sarcopenia or Type 2 Diabetes Mellitus measured by Nailfold videocapillaroscopy and venous occlusion plethysmography before and after 14 days of consumption 5g oral L-arginine supplementation.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Rio de Janeiro State University","enrollment":120,"countries":["Brazil"],"start_date":"2016-04-01","completion_date":"2019-09-01","last_update_date":"2019-10-02","source_url":"https://clinicaltrials.gov/study/NCT04112875","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:09.013623+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"20 Years to 85 Years","comparator":"L-arginine; Maltodextrin","organization":"Rio de Janeiro State University","interventions":["L-arginine","Maltodextrin"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Changes in Microcirculation — before and after 14 days of intervention","Changes in Endothelium-dependent and endothelium-independent vasodilation — before and after 14 days of intervention","Change in metabolic markers — before and after 14 days of intervention","change in circulating muscle growth and degradation factors — before and after 14 days of intervention","Body composition by DXA — before of intervention"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Sarcopenia","Type 2 Diabetes","Microcirculation","L-arginine","Maltodextrin"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct04112875","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-04-01 to 2019-09-01","comparator":"L-arginine; Maltodextrin","confidence":"structured-source","population":"FEMALE · 20 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.890Z","intervention":["L-arginine","Maltodextrin"],"participants":120,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Changes in Microcirculation — before and after 14 days of intervention","Changes in Endothelium-dependent and endothelium-independent vasodilation — before and after 14 days of intervention","Change in metabolic markers — before and after 14 days of intervention","change in circulating muscle growth and degradation factors — before and after 14 days of intervention","Body composition by DXA — before of intervention"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/33327","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}