{"type":"trials","record":{"id":33784,"source_id":"clinicaltrials-gov","external_id":"NCT06955975","title":"The Effect of Pectin Supplementation on Geriatric With Frailty: A Randomised Placebo-Controlled Dietary Intervention Study","brief_summary":"The study involves the intake of Low-methoxy (LM) pectin (polysaccharides extracted from citrus peels), which are commonly found in the UK diet (not pharmacological agents), to test their effects on systematic inflammation in the body and gut microbiome composition. Study subjects will be healthy elderly with early signs of frailty or pre-frailty from the local population and will be asked to attend the laboratory on 2 occasions; before and after 4-week' supplementing the diet daily with either 10g of pectin with 10g of whey protein and 10g of cocoa powder added as flavour (active arm) or 10g of whey protein with 10g of cocoa powder added as flavour (placebo). Participants will be given the blinded products portioned in individual sachets, with instructions to add the contents of one sachet a day to 150ml of milk and to consume immediately. At each study visit (\\~90 minutes), participants will be asked to provide a stool and blood sample, will have blood pressure, heart rate, weight, height, and waist/hip ratio measured, research team will perform physical functioning test (Time up and go test, 30-second sit to stand test) as well as participants will complete the quality-of-life questionnaire (SF-36), the Depression and Anxiety (HADS) and the Gastrointestinal Symptom Rating Scale (GSRS).","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Nottingham","enrollment":30,"countries":["United Kingdom"],"start_date":"2025-02-10","completion_date":"2026-03-31","last_update_date":"2025-06-22","source_url":"https://clinicaltrials.gov/study/NCT06955975","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:11.953004+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"GEOFF","age_range":"65 Years","comparator":"Pectin; Whey protein","organization":"University of Nottingham","interventions":["Pectin","Whey protein"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in microbiome profile — 4 weeks","Change in inflammatory profile — 4 weeks","Changes in short chain fatty acids (SCFAs) — 4 weeks","Change in systolic blood pressure (lying to standing) pre intervention — 4 minutes","Change in systolic blood pressure (lying to standing) post intervention — 4 minutes","Change in diastolic blood pressure (lying to standing) pre intervention — 4 minutes","Change in diastolic blood pressure (lying to standing) post intervention — 4 minutes","Change in body mass index (BMI) — 4 weeks","Change in waist-to-hip ratio (WHR) — 4 weeks","Change in time up and go test (TUG) — 4 weeks","Change in 30-second sit to stand test — 4 weeks","Change in Hospital Anxiety and Depression Score (HADS) — 4 weeks","Change in 36-Item Short Form Survey (SF-36) Questionnaire — 4 weeks"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · QUADRUPLE","source_has_results":false},"controlled_terms":["Frailty at Older Adults","Pre-Frailty","Frailty","Diet","Dietary Fiber","Systemic Inflammatory Response","Pectin","Whey protein"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06955975","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-02-10 to 2026-03-31","comparator":"Pectin; Whey protein","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.503Z","intervention":["Pectin","Whey protein"],"participants":30,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in microbiome profile — 4 weeks","Change in inflammatory profile — 4 weeks","Changes in short chain fatty acids (SCFAs) — 4 weeks","Change in systolic blood pressure (lying to standing) pre intervention — 4 minutes","Change in systolic blood pressure (lying to standing) post intervention — 4 minutes","Change in diastolic blood pressure (lying to standing) pre intervention — 4 minutes","Change in diastolic blood pressure (lying to standing) post intervention — 4 minutes","Change in body mass index (BMI) — 4 weeks","Change in waist-to-hip ratio (WHR) — 4 weeks","Change in time up and go test (TUG) — 4 weeks","Change in 30-second sit to stand test — 4 weeks","Change in Hospital Anxiety and Depression Score (HADS) — 4 weeks","Change in 36-Item Short Form Survey (SF-36) Questionnaire — 4 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/33784","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}