{"type":"trials","record":{"id":338,"source_id":"clinicaltrials-gov","external_id":"NCT07790263","title":"Effects of a Smart Circuit Exercise Program on Health Outcomes in Community-Dwelling Older Adults","brief_summary":"This study was conducted in collaboration with a community-based retirement facility to evaluate the clinical effectiveness of a smart, technology-assisted circuit exercise intervention for community-dwelling older adults. Traditional exercise prescriptions for older adults often lack real-time monitoring of individual physiological responses, which can increase the risk associated with exercise participation. This program integrated real-time physiological monitoring (including heart rate reserve, HRR) to guide individualized exercise intensity within a moderate-intensity range (50%-60% HRR). The study was conducted in two stages with different allocation designs: Stage 1 (Randomized Controlled Design): Participants were randomly assigned to either an intervention group or a control group. The intervention group received the smart circuit exercise program, while the control group did not receive the exercise intervention and underwent pre- and post-assessment only. This stage allowed for between-group comparison of intervention effects. Stage 2 (Single-Group Extension): Following completion of Stage 1, the facility extended the exercise program to a broader group of community residents as part of a real-world implementation and scale-up initiative, in order to evaluate the program under routine practice conditions and to provide equitable access to the intervention across the community. A concurrent control group was not maintained during this stage, consistent with its focus on real-world effectiveness evaluation rather than efficacy comparison. Participants in both stages received circuit-based exercise training three times per week (24 sessions total over approximately 8 weeks), with intensity controlled at 50%-60% heart rate reserve (HRR). Outcome measures assessed before and after the intervention period included: cardiac autonomic activity and hemodynamic function (including blood pressure and heart rate variability), arterial stiffness, body composition (including skeletal muscle mass, body fat mass, and body fat percentage), functional fitness (including lower limb muscle strength and dynamic balance), clinical blood biochemistry indicators (including HbA1c), depressive symptoms (CESD-10), and sleep quality (Pittsburgh Sleep Quality Index, PSQI). Statistical analyses varied by stage and publication. For Stage 1 between-group comparisons, linear mixed models (LMM) with participant as a random intercept were used to test Time × Group interactions, adjusting for age, sex, and height. For broader cohort analyses, two-way mixed-design analysis of variance and paired-samples t-tests were used. Statistical significance was set at alpha = .05 for all analyses.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Chang Gung Memorial Hospital","enrollment":256,"countries":["Taiwan"],"start_date":"2024-05-10","completion_date":"2026-02-28","last_update_date":"2026-08-27","source_url":"https://clinicaltrials.gov/study/NCT07790263","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:02.6738+00:00","last_seen_at":"2026-09-25T06:10:49.917+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 85 Years","comparator":"Arm 2_Stage 1 - Control Group","organization":"Chang Gung Memorial Hospital","interventions":["Smart Circuit Exercise Program"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Time-Domain Heart Rate Variability — Baseline and up to 12 weeks","Change in Frequency-Domain Heart Rate Variability — Baseline and up to 12 weeks","Change in Dynamic Heart Rate Variability Reactivity — Baseline and up to 12 weeks","Change in Blood Pressure — Baseline and up to 12 weeks","Change in Rate-Pressure Product — Baseline and up to 12 weeks","Change in Skeletal Muscle Mass and Body Fat Mass — Baseline and up to 12 weeks","Change in Percent Body Fat — Baseline and up to 12 weeks","Change in Body Mass Index — Baseline and up to 12 weeks","Change in Waist-Hip Ratio — Baseline and up to 12 weeks","Change in Visceral Fat Area — Baseline and up to 12 weeks","Change in Digital Volume Pulse Stiffness Index — Baseline and up to 12 weeks","Change in Digital Volume Pulse Contour Reflection Index — Baseline and up to 12 weeks","Change in Second-Derivative Photoplethysmogram Amplitude Ratios — Baseline and up to 12 weeks","Change in Augmentation Index — Baseline and up to 12 weeks","Change in Aging Index — Baseline and up to 12 weeks","Change in Lower- and Upper-Limb Muscular Strength — Baseline and up to 12 weeks","Change in Lower- and Upper-Limb Flexibility — Baseline and up to 12 weeks","Change in Cardiorespiratory Endurance — Baseline and up to 12 weeks","Change in Dynamic and Static Balance — Baseline and up to 12 weeks","Change in HbA1c — Baseline and up to 12 months following study completion"],"design_description":"NON RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Aging","Autonomic Nervous System","Hemodynamics","Smart Circuit Exercise Program"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:57.79658+00:00","duplicate_cluster_key":"id:nct07790263","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-05-10 to 2026-02-28","comparator":"Arm 2_Stage 1 - Control Group","confidence":"structured-source","population":"ALL · 65 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:49.919Z","intervention":["Smart Circuit Exercise Program"],"participants":256,"study_design":"NON RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Time-Domain Heart Rate Variability — Baseline and up to 12 weeks","Change in Frequency-Domain Heart Rate Variability — Baseline and up to 12 weeks","Change in Dynamic Heart Rate Variability Reactivity — Baseline and up to 12 weeks","Change in Blood Pressure — Baseline and up to 12 weeks","Change in Rate-Pressure Product — Baseline and up to 12 weeks","Change in Skeletal Muscle Mass and Body Fat Mass — Baseline and up to 12 weeks","Change in Percent Body Fat — Baseline and up to 12 weeks","Change in Body Mass Index — Baseline and up to 12 weeks","Change in Waist-Hip Ratio — Baseline and up to 12 weeks","Change in Visceral Fat Area — Baseline and up to 12 weeks","Change in Digital Volume Pulse Stiffness Index — Baseline and up to 12 weeks","Change in Digital Volume Pulse Contour Reflection Index — Baseline and up to 12 weeks","Change in Second-Derivative Photoplethysmogram Amplitude Ratios — Baseline and up to 12 weeks","Change in Augmentation Index — Baseline and up to 12 weeks","Change in Aging Index — Baseline and up to 12 weeks","Change in Lower- and Upper-Limb Muscular Strength — Baseline and up to 12 weeks","Change in Lower- and Upper-Limb Flexibility — Baseline and up to 12 weeks","Change in Cardiorespiratory Endurance — Baseline and up to 12 weeks","Change in Dynamic and Static Balance — Baseline and up to 12 weeks","Change in HbA1c — Baseline and up to 12 months following study completion"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/338","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}