{"type":"trials","record":{"id":33806,"source_id":"clinicaltrials-gov","external_id":"NCT06882941","title":"Modulation of the Gut Microbiota and Metabolism in Elderly by Algae Products.","brief_summary":"The goal of this clinical trial is to determine whether a fermented black soybean and adlay supplement can improve frailty. The main questions it seeks to answer are: * Does the fermented black soybean and adlay supplement improve physical performance? * What is the effect of the fermented black soybean and adlay supplement on gut microbiota? Researchers will compare the fermented black soybean and adlay supplement to a placebo (a non-fermented black soybean and adlay supplement) to assess its impact on physical performance. Participants will: * Take either the fermented black soybean and adlay supplement or a placebo daily for 12 weeks. * Visit the clinic for checkups and tests before and after consuming the product.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National Taiwan University Hospital","enrollment":141,"countries":["Taiwan"],"start_date":"2018-12-12","completion_date":"2021-04-16","last_update_date":"2025-03-19","source_url":"https://clinicaltrials.gov/study/NCT06882941","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:11.953004+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Non-Fermented Black Soybean and Adlay Supplement","organization":"National Taiwan University Hospital","interventions":["Fermented Black Soybean and Adlay Supplement","non-fermented black soybean and adlay supplement"],"registry_source":"ClinicalTrials.gov","outcome_measures":["frailty status — From enrollment to the end of treatment at 12 weeks","gut microbiota — From enrollment to the end of treatment at 12 weeks","Physical performance: 5-meter walk speed — From enrollment to the end of treatment at 12 weeks","physical performance: Timed Up and Go test — From enrollment to the end of treatment at 12 weeks","physical performance: 30-second chair stand test — From enrollment to the end of treatment at 12 weeks","physical performance: grip strength — From enrollment to the end of treatment at 12 weeks","Number of participants with biochemistry blood tests. — From enrollment to the end of treatment at 12 weeks"],"design_description":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","source_has_results":false},"controlled_terms":["Frailty","Fermented Black Soybean and Adlay Supplement","non-fermented black soybean and adlay supplement"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: gut microbiota.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06882941","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-12-12 to 2021-04-16","comparator":"Non-Fermented Black Soybean and Adlay Supplement","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.519Z","intervention":["Fermented Black Soybean and Adlay Supplement","non-fermented black soybean and adlay supplement"],"participants":141,"study_design":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["frailty status — From enrollment to the end of treatment at 12 weeks","gut microbiota — From enrollment to the end of treatment at 12 weeks","Physical performance: 5-meter walk speed — From enrollment to the end of treatment at 12 weeks","physical performance: Timed Up and Go test — From enrollment to the end of treatment at 12 weeks","physical performance: 30-second chair stand test — From enrollment to the end of treatment at 12 weeks","physical performance: grip strength — From enrollment to the end of treatment at 12 weeks","Number of participants with biochemistry blood tests. — From enrollment to the end of treatment at 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"microbiome-dysbiosis","is_published":true,"match_reasons":["Title contains controlled term: gut microbiota.","Abstract contains controlled term: gut microbiota.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Microbiome and dysbiosis","slug":"microbiome-dysbiosis"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/33806","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}