{"type":"trials","record":{"id":34041,"source_id":"clinicaltrials-gov","external_id":"NCT04112043","title":"Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)","brief_summary":"More than 80% of older adults have hypertension, with higher prevalence of high systolic blood pressure (SBP) putting them at high risk for cardiovascular (CV) disease and death. Novel compound, nicotinamide riboside may enhance the effects of exercise therapy in hypertensive older adults.","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"University of Florida","enrollment":147,"countries":["United States"],"start_date":"2020-07-28","completion_date":"2023-05-26","last_update_date":"2024-06-06","source_url":"https://clinicaltrials.gov/study/NCT04112043","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:20:13.198107+00:00","last_seen_at":"2026-09-25T06:10:49.917+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years to 105 Years","comparator":"NR plus Walking Exercise; Walking Exercise plus Placebo; NR Alone","organization":"University of Florida","interventions":["Walking Exercise","Nicotinamide Riboside (NR)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Daytime Systolic Blood Pressure — Baseline; Week 6","Change in Arterial Stiffness — Baseline; Week 6"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","source_has_results":true},"controlled_terms":["Hypertension","Walking Exercise","Nicotinamide Riboside (NR)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: nicotinamide riboside.","quality_checked_at":"2026-09-25T06:10:57.79658+00:00","duplicate_cluster_key":"id:nct04112043","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-07-28 to 2023-05-26","comparator":"NR plus Walking Exercise; Walking Exercise plus Placebo; NR Alone","confidence":"structured-source","population":"ALL · 55 Years to 105 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:49.941Z","intervention":["Walking Exercise","Nicotinamide Riboside (NR)"],"participants":147,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Daytime Systolic Blood Pressure — Baseline; Week 6","Change in Arterial Stiffness — Baseline; Week 6"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"nad-metabolism","is_published":true,"match_reasons":["Title contains controlled term: nicotinamide riboside.","Abstract contains controlled term: nicotinamide riboside.","Source terminology contains: nicotinamide riboside.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"NAD metabolism","slug":"nad-metabolism"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/34041","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}